NEURONAL GLUCOSE DETECTION & HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 强化胰岛素治疗是预防所有I型糖尿病患者以及许多2型糖尿病患者高血糖所致损害的唯一方法。然而，胰岛素治疗会产生威胁生命的副作用低血糖。此外，即使是一次低血糖，大脑也无法检测到未来的低血糖发作。这种综合征统称为低血糖相关自主神经衰竭(HAF)和低血糖无意识，可使血糖水平在未被检测到的情况下降至严重甚至致命的水平。我们的目标是了解大脑感知葡萄糖的能力是如何在反复低血糖导致HAAF的过程中受损的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Intensive insulin therapy is the only way to prevent hyperglycemia-induced damage in all patients with Type I, and many with Type 2, Diabetes Mellitus. However, insulin therapy produces a life-threatening side effect  hypoglycemia. Moreover, even on bout of hypoglycemia renders the brain unable to detect future hypoglycemia episodes. This syndrome, known collectively as hypoglycemia-associated autonomic failure (HAAF) and hypoglycemia unawareness, allows blood glucose levels to fall to severe, even lethal, levels without detection. It is our goal to understand how the brain's ability to sense glucose becomes impaired during recurrent hypoglycemia leading to HAAF.