MOUSE MODEL RESOURSE

小鼠模型资源(MMR)为TJL癌症中心的研究人员提供访问 从TJL的遗传资源中获得的2900个公开可用的菌株中，大约有800个 存储库。MMR还提供了有关这些菌株的信息，以及科学家在 遗传资源计划。实时资源，以及可从 超低温保存资源包括遗传资源库，是最大的单一收藏 世界上任何地方的基因定义的小鼠品系。鼠标模型资源提供TJL 癌症中心会员带少量小鼠免费从储存库中取出。癌症中心 成员可以从突变菌株获得育种对和少量突变体和对照，或者 来自品系板的单个小鼠。癌症中心成员通过进一步增加菌株的价值 这些科学信息被添加到菌株信息数据库中，从结果 或通过电子方式直接传输到用于应变板的老鼠表型组数据库。这个 资源包含携带自发、诱导和基因工程突变的小鼠品系； 有染色体异常的小鼠；特殊的近交系和品系组，包括野生来源的 近交系、同源、重组自交系(RL)和共生体品系。投保损失保险和 对需求极低的品系进行经济管理，所有品系都作为胚胎或配子进行超低温保存 通过生殖科学计划，大多数品系的DNA都可以通过小鼠获得 基因组科学中的DNA资源。遗传资源技术信息科学家收集、整理、 并维护有关这些菌株的操作和科学信息。鼠标模型资源 工作人员提供遗传专业知识和建议，以及群体维护建议，包括特别 畜牧业需求和生物学信息，关于资源中的老鼠。资源人员还 提供一支拥有多年经验和广泛知识和专业技能的遗传学家核心 在与基因作图、小鼠遗传学、小鼠饲养和生物学相关的各种领域。这个 MMR在32号楼和功能基因组学中占据了7,345平方英尺的空间和程序空间 大楼。穆里尔·戴维森博士，高级职员科学家，遗传资源主任，项目负责人 负责鼠标模型资源项目的相互管理和协调 与TJL的其他资源和科学服务。

The Mouse Models Resource (MMR) provides TJL Cancer Center investigators with access to approximately 800 of the 2,900 publicly available strains available from TJL's Genetic Resource Repository. The MMR also provides information about these strains, and the expertise of scientists in the Genetic Resource Program. The live Resource, together with Resource strains available from the Cryopreservation Resource comprises the Genetic Resource Repository and is the largest single collection of genetically defined mouse strains anywhere in the world. The Mouse Models Resource provides TJL Cancer Center members with small numbers of mice from the Repository free of charge. Cancer Center members can obtain breeding pairs and small numbers of mutants and controls from mutant strains, or individual mice from strain panels. Cancer Center members add value to the strains by further characterizing them; this scientific information is added to the strain information database from resulting publications or by electronic transmission directly into the Mouse Phenome Database for strain panels. The Resource contains mouse strains carrying spontaneous, induced, and genetically engineered mutations; mice with chromosome aberrations; and special inbred strains and strain panels, including wild-derived inbred, congenic, Recombinant Inbred (Rl), and consomic strains. For insurance against loss and economic management of very low demand strains, all strains are cryopreserved as embryos or gametes through the Reproductive Sciences program, and DNA from most strains is available through the Mouse DNA Resource in Genome Sciences. Genetic Resource Technical Information Scientists gather, curate, and maintain the operational and scientific information about these strains. Mouse Models Resource personnel provide genetic expertise and advice, and colony maintenance advice, including special husbandry needs and biological information, about the mice in the Resource. Resource personnel also provide a core of geneticists who have many years of experience and extensive knowledge and expertise in a variety of areas related to gene mapping, mouse genetics, and mouse husbandry and biology. The MMR occupies 7,345 ft2 of vivarium and procedure space in Building 32 and the Functional Genomics Building. Dr. Muriel Davisson, Senior Staff Scientist, Director of Genetic Resources, is the Project Leader responsible for administration and coordination of Mouse Models Resource programs with each other and with other Resources and Scientific Services at TJL.