Identification of host restriction factors that block respiratory virus infection

吸入后，呼吸道病毒可以感染并在呼吸道上皮细胞中生长。虽然巨噬细胞等免疫细胞也容易感染，但这通常是流产的，不会释放新的病毒。该项目将识别巨噬细胞中诱导的蛋白质，这些蛋白质可以阻止呼吸道病毒并防止它们在呼吸道中传播。我们还将确定一些毒力菌株克服这一障碍在巨噬细胞中生长的机制。

Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also susceptible to infection, this is generally abortive and new viruses are not released. This project will identify proteins induced in macrophages that block respiratory viruses and prevent their spread in the airways. We will also define mechanisms by which some virulent strains overcome this block to grow in macrophages.