High Throughput Screening for Advanced Scintillation Detectors

描述(由申请人提供)：该SBIR项目的目标是使用高效的组合筛选过程，快速发现先进的闪烁体，用于许多医学成像探测器。在第一阶段，我们已经开发并论证了一套新的组合筛选工具的可行性，以快速合成大量微型闪烁体，准确地再现了许多著名闪烁体的晶相。在二期项目中，独特的一套高效闪烁体研发工具将被广泛应用于寻找先进的Ce激活的重金属氧化物和卤化物闪烁体。利用这套组合闪烁体工具，将在2年的项目中合成至少12,000种不同的氧化物和卤化物闪烁体并对其进行表征。其具体目标是发现一种新的单晶闪烁体相，与最先进的医用探测器闪烁体，如Lu2SiO5：Ce3+相比，具有更高的光度、更快的荧光衰减时间和更低的材料成本。 与公共卫生相关：闪烁体是一种关键的探测器材料，被用于许多主要的医疗诊断系统，包括射线照相、乳房X光照相、血管照相、心血管和透视成像、计算机断层扫描、单光子发射计算机断层扫描、正电子发射断层扫描等。这些医疗系统的性能在很大程度上取决于闪烁体的性能，例如，更高亮度的闪烁体可以在早期更灵敏和准确地检测疾病，从而挽救生命。该项目中将发现的先进闪烁体将显著改进许多医学成像探测器。

DESCRIPTION (provided by applicant): The objective of this SBIR project is to rapidly discover advanced scintillators for applications in many medical imaging detectors, using an efficient combinatorial screening process. In Phase I, we have developed and demonstrated the feasibility on a set of novel combinatorial screening tools, to rapidly synthesize large collection of scintillators in miniature forms, which accurately reproduced the crystalline phases of many well-known scintillators. In Phase II project, the unique set of efficient scintillator R&D tools will be broadly applied to search for advanced Cerium activated heavy metal oxides and halides scintillators. With the set of combinatorial scintillator tools, at least 12,000 different oxides and halides scintillators will be synthesized and characterized in the 2 year project. The specific aim is to discover a new single crystal scintillator phase with superior luminosity, faster fluorescent decay time, and lower material cost than state-of-the-art medical detector scintillator, e.g. Lu2SiO5:Ce3+. PUBLIC HEALTH RELEVANCE: Scintillator is a key detector material being used in many major medical diagnosis systems, including radiography, mammography, angiography, cardiovascular and fluoroscopic imaging, computed tomography, single photon emission computed tomography, positron emission tomography, etc. The performance of these medical systems, to a large extent, depends on the properties of scintillators, for example, scintillators with higher luminosity results in more sensitive and accurate detection of diseases at early stages which could save lives. Advanced scintillators that will be discovered in the project will significantly improve many medical imaging detectors.