Wound Decontamination for the Prevention and Treatment of Multi-drug Resistant Ba

描述（由申请人提供）：多重耐药感染的频率正以惊人的速度增加。同样令人关切的是，可用于有效治疗的治疗选择有限，导致与这些高度耐药感染相关的发病率和死亡率增加。通常，多重耐药感染表现为由耐甲氧西林金黄色葡萄球菌（MRSA）和其他多重耐药细菌引起的软组织或伤口感染。拟议的项目侧重于开发一种无毒的局部冲洗产品。这种伤口去污剂能够帮助清除伤口上的细菌，杀死广谱的耐药和非耐药细菌，并提供残留的预防作用，防止细菌定植。通过聚集细菌，感染性病原体更容易从伤口中冲洗出来。任何未被清除的细菌都被聚合物衍生物杀死，残留的物质阻止细菌定植。这项工作优化了所需的浓度和分子的特定分子量配方，以促进伤口清洁和保护免受后续感染。这些研究将导致II期体内研究，以支持所需的监管申请。目标是为伤口感染的治疗和预防提供一种新颖，高效和高度生物相容性的治疗方法，特别是针对多重耐药细菌。

DESCRIPTION (provided by applicant): The frequency of multi-drug resistant infections is increasing at an alarming rate. Equally concerning is the limited therapeutic options available for effective treatment, resulting in increased morbidity and mortality associated with these highly resistant infections. Frequently, multi-drug resistant infections manifest as soft tissue or wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and other multi-drug resistant bacteria. The proposed project focuses on the development of a non-toxic, topical rinse product. This wound decontaminant is capable of helping to clear bacteria from wound, killing a broad spectrum of resistant and non-resistant bacteria, and providing a residual prophylactic effect that prevents bacterial colonization. By aggregating bacteria, the infectious pathogens are more easily rinsed from the wound. Any bacteria not removed are killed by the polymer derivative and residual material prevents bacterial colonization. This proposed work optimizes the concentration required and specific molecular weight formulation of the molecule to facilitate wound cleaning and protection from subsequent infection. These studies will lead to in vivo studies in Phase II in support of required regulatory applications. The goal is to provide a novel, highly effective and highly biocompatible therapy for the treatment and prevention of wound infections, particularly addressing bacteria that are multi-drug resistant. PUBLIC HEALTH RELEVANCE: A natural antimicrobial polymer derivative has been developed that demonstrates broad-spectrum antibacterial activity against multi-drug resistant and non-resistant bacteria. The polymer is a biocompatible, non-toxic polysaccharide, is not absorbed or metabolized by the body, and is ideal for topical applications. Further, because the mechanism of action of the molecule with bacteria is physical membrane damage, the polymer is less likely to evoke antibiotic resistance. Our aims focus on the characterization and development of a non-toxic, efficacious wound decontamination rinse for prevention and treatment of multi-drug resistant wound infections. The optimized formulation is expected to facilitate the removal of pathogenic bacteria via clumping, reducing the viability of remaining bacteria and providing a limited residual barrier to bacterial colonization. This proposed research is intended to understand and optimize the molecular variables associated with clumping, bactericide and residual effect and ultimately provide a novel therapeutic product to prevent and treat multi-drug resistant wound infections.