Core--Biochemistry and Signal Transduction

生化核心和信号转导核心是分开的单元。由于它们使用了类似的方法，并使用了可以在两个岩心中执行某些分析的人员，因此在此次更新申请中结合了它们。此外，信号转导核心在当前资助期间的部分工作包括开发方法和识别受体和其他信号分子中的遗传变异。这些工作现在将由Core D负责。生物化学和信号传输核心的结合将使核心董事的综合工作从10%减少到8%，并允许人员共同努力，从而实现更有效的运营。由此产生的效率反映在预算中，低于目前运行的两个核心的总和预算。尽管美国政府执行的分析总数 岩心不会减少，实验室人员现在更熟悉进行大容量分析，因此可以更有效地进行分析。不幸的是，这些化验用品的价格没有下降，因此我们无法像减少人员预算那样减少供应预算。

The Biochemistry Core and Signal Transduction Core were separate units. They have been combined in this renewal application since they utilize similar methods and utilize personnel who can perform some of the assays in both cores. In addition, part of the efforts of the Signal Transduction Core during the current funding period involved development of methods and identification of genetic variants in receptors and other signaling molecules. These efforts will now be undertaken by Core D. The combination of the Biochemistry and Signal Transduction Cores will permit more efficient operation by decreasing the combined effort of the core directors from 10% to 8% and by allowing personnel to combine efforts. The resulting efficiencies are reflected in the budget, which is less than the combined budgets of the two cores currently in operation. Although the total number of assays performed by the cores will not decrease, laboratory personnel are now more familiar with performing high volume assays, and can thus carry them out more efficiently. Unfortunately, supplies for these assays have not gone down in price, so we have not been able to decrease the supply budget as much as the personnel budget.