Identification of novel genes predisposing to familial colorectal cancer by full exome sequencing

三分之一的肠癌患者有家族病史。目前，我们只了解这些家族中的一小部分涉及的基因。这项提议将使用新的基因技术，通过同时对一个人的所有基因进行测序，来寻找剩余家庭中的基因缺陷。通过识别新的基因，我们可以准确地评估家庭成员患肠癌的风险，有效地针对监测，并帮助降低他们患肠癌的风险。

A third of people who develop bowel cancer have a family history of the condition. Currently, we only understand the genes involved in a small number of these families. This proposal will use new genetic techniques to look for gene faults in the remaining families by sequencing all an individual’s genes simultaneously. By identifying new genes, we can accurately assess family members’ bowel cancer risk, effectively target surveillance and help reduce their risk of developing bowel cancer.