Fast numerical modeling of medical ultrasound for therapy and imaging

描述（由申请人提供）：这项工作的总体目标是扩展和优化模拟软件，以快速准确地对超声治疗和成像进行计算机模拟。该软件将减少时间密集型治疗和成像模拟所需的时间，相对于竞争程序至少减少一个或两个数量级，同时提高近场区域的准确性，将允许用户快速构建用于治疗和诊断应用的超声相控阵列模型，然后快速计算这些模型生成的压力场和图像。目前需要数天或数周的大规模模拟将在数小时内完成，标准模拟将在数分钟内完成。该软件支持所有最常见的医疗超声换能器几何形状，既可用于单个元件的模拟，也可用于平面和弯曲的1D和2D相控阵列的模拟。这项工作的具体目标是：1）扩展和改进时谐激励驱动的超声换能器和相控阵的快速压力场模拟，2）扩展和增强瞬态激励驱动的超声换能器和相控阵的快速压力场模拟，以及3）增强和优化相控阵超声成像模拟的快速例程。目标1将支持加速线性和非线性超声模拟的开发，主要用于治疗应用，包括HIFU（高强度聚焦超声）。目标2将支持开发用于瞬态治疗和诊断应用的快速线性和非线性模拟软件，目标3将支持开发超声成像的快速线性和非线性模拟。这种集中的快速，强大的超声模拟程序库已经过彻底的测试和调试，将有助于快速评估超声相控阵系统的治疗和成像研究。通过这项工作创建的软件将解决治疗超声界长期以来对专门为三维（3D）HIFU（高强度聚焦超声）模拟设计的公开程序的需求。这些计划还将满足超声成像研究对更好、更快的模拟软件的需求。 公共卫生相关性：通过这项工作创建的软件将解决治疗超声界长期以来对专门为三维（3D）HIFU（高强度聚焦超声）模拟设计的公开程序的需求。这些计划还将满足超声成像研究对更好、更快的模拟软件的需求。!

DESCRIPTION (provided by applicant): The overall objective of this effort is to extend and optimize simulation software for rapid and accurate computer simulations of ultrasound therapy and imaging. This software, which will reduce the time required for time-intensive therapy and imaging simulations by at least one or two orders of magnitude relative to competing programs while simultaneously improving the accuracy achieved in the nearfield region, will allow users to quickly construct ultrasound phased array models for therapeutic and diagnostic applications and then rapidly calculate the pressure fields and images that are generated by these models. Large-scale simulations that presently take days or weeks will be completed in hours, and standard simulations will be completed in minutes. All of the most common medical ultrasound transducer geometries will be supported by this software, both for simulations of single elements and for simulations of flat and curved 1D and 2D phased arrays. The specific aims of this effort are: 1) to extend and improve fast pressure field simulations for ultrasound transducers and phased arrays driven by time-harmonic excitations, 2) to expand and enhance fast pressure field simulations for ultrasound transducers and phased arrays driven by transient excitations, and 3) to augment and optimize fast routines for simulations of phased array ultrasound imaging. Aim 1 will support the development of accelerated linear and nonlinear ultrasound simulations that are primarily intended for therapeutic applications, including HIFU (high intensity focused ultrasound). Aim 2 will support the development of rapid linear and nonlinear simulation software for transient therapeutic and diagnostic applications, and Aim 3 will support the development of fast linear and nonlinear simulations of ultrasound imaging. This centralized repository of fast, robust ultrasound simulation routines that have been thoroughly tested and debugged will facilitate rapid evaluation of ultrasound phased array systems for therapy and imaging research. The software created by this effort will address a longstanding need in the therapeutic ultrasound community for publicly available programs designed specifically for three dimensional (3D) HIFU (high intensity focused ultrasound) simulations. These programs will also address the need for better, faster simulation software for ultrasound imaging research. PUBLIC HEALTH RELEVANCE: The software created by this effort will address a longstanding need in the therapeutic ultrasound community for publicly available programs designed specifically for three dimensional (3D) HIFU (high intensity focused ultrasound) simulations. These programs will also address the need for better, faster simulation software for ultrasound imaging research. !