Identification of in vivo substrates of muscle atrophy-related ubiquitin ligases MAFbx and MuRF1

肌肉萎缩（也称为萎缩）发生在许多不同的疾病中，例如糖尿病和癌症，也发生在病人在事故或手术后无法活动时。在这些病例中发生的肌肉损失是影响恢复时间的主要因素之一，或者患者是否完全康复。此外，随着年龄的增长，肌肉萎缩也会发生，这是导致行动能力丧失的一个因素。为了开发药物和治疗方法来帮助控制肌肉萎缩，并提高受肌肉萎缩影响的人们的生活质量，我们需要更好地了解肌肉细胞发生的变化。特别是，我们需要知道组成肌肉的蛋白质发生了什么，并使其正常运作。该应用程序旨在找出肌肉萎缩过程中人体肌肉蛋白发生的最重要变化，这应该使我们能够在未来开发出更好的治疗这些疾病的方法。

Muscle wasting (also known as atrophy) occurs in many different diseases, for example in diabetes and cancer, and also when patients are immobilised following accidents or surgery. The loss of muscle that occurs in these cases is one of the major factors affecting recovery time, or indeed whether or not the patients do fully recover. In addition, as we get older, muscle wasting also occurs, which is one factor that can lead to loss of mobility. In order to develop drugs and therapies to help control muscle wasting, and to increase the quality of life for people affected by muscle wasting, we need a much better understanding of the changes which occur in muscle cells. In particular, we need to know what happens to the proteins which make up the muscle, and allow it to function properly. This application aims to work out the most important changes which occur in human muscle proteins during muscle wasting, which should allow us to develop better treatments for these conditions in the future.