Identification of PACE-1 as a novel therapeutic target for the treatment of prostate cancer

晚期前列腺癌（PCa）仍然是主要的治疗挑战，因为在这个阶段，手术和全身治疗都无效。最近，我们发现了一种叫做PACE-1的蛋白质，它对前列腺癌细胞的存活至关重要。我们计划研究PACE-1在前列腺癌发生发展中的作用。然后，我们将测试单独或联合全身癌症治疗是否会抑制前列腺肿瘤的生长和疾病进展。

Advanced prostate cancer (PCa) remains the major therapeutic challenge since neither surgery nor systemic therapies are effective at this stage. Recently, we identified a protein called PACE-1 that is essential for PCa cell survival. We plan to investigate the roles of PACE-1 in the development and progression of prostate cancer. We will then test if PACE-1 inactivation alone or in combination with systemic cancer therapies will inhibit prostate tumor growth and disease progression.