A UK resource of new models of bone and mineral disorders

遗传异常在导致许多常见的人类骨骼、关节疾病和构成这些疾病的重要矿物质方面是很重要的。这些条件加在一起几乎影响到所有人。对小鼠的研究对于理解基因在这些疾病中的作用很重要，因为有许多实验可以在小鼠身上进行，而这些实验在伦理上和实际原因上都不可能在人类身上进行。目前有许多情况没有确定小鼠模型。该计划将系统地培育新的小鼠品系，以识别与骨质疏松症、骨关节炎、痛风、癌症和肾结石等疾病相关的小鼠表型。确定这些小鼠的基因将有助于我们了解是什么导致了人类同样的情况。这一知识将导致针对人类这些疾病的新疗法的发展。

Genetic abnormalities are important in the causation of many common human diseases of bones, joints and the minerals important in their makeup. These conditions combined affect nearly all humans. Studies of mice are important in understanding the role of genes in these diseases, as there are many experiments that can be performed with mice that are impossible in humans both ethically and for practical reasons. Currently there are many conditions for which no mouse model has been identified. This programme will systematically breed new mouse strains to identify mice developing phenotypes relevant to conditions such as osteoporosis, osteoarthritis, gout, cancer and kidney stones. Identifying the genes involved in these mice will help us to understand what causes the same conditions in humans. This knowledge will lead to the development of new treatments for these conditions in humans.