The NCJDSU Tissue Resource: support for continued banking activities

朊病毒疾病是影响大脑的致命疾病，包括疯牛病或？疯牛病？牛和人类的克雅氏病一种形式的克雅氏病，称为变异型克雅氏病，与通过饮食接触疯牛病有关。朊病毒疾病是可传播的，对克雅氏病和疯牛病的研究表明，这种传染性病原体在大脑中积累的水平最高。然而，该试剂也可以存在于整个身体的一系列其他组织中。这项研究的目的是继续收集和储存组织从所有形式的克雅氏病在银行的国家克雅氏病监测单位，爱丁堡。该库在发现变异型CJD中发挥了关键作用，并被英国和世界各地的广泛研究人员使用。所收集的材料来自疑似克雅二氏症患者尸检时取得的组织和器官，但必须得到亲属的同意。我们还收集了活着的病人的血液样本，同样是在亲属的同意下。该银行已获得我们当地伦理委员会的批准，并已用于许多研究项目，导致重大科学和医学出版物。这项研究的信息也对NHS的工作产生了重大影响，特别是在采取措施减少通过输血和手术器械传播变异型CJD的机会方面。我们相信，英国和其他地方的研究人员未来将继续需要该银行，因为关于这组疾病还有很多悬而未决的问题。还有一个主要的需要，以帮助开发一种测试克雅氏病，可用于活的病人，这将有助于使用组织和血液样本在我们的银行。我们根据MRC的指导方针经营银行，并计划使用MRC指导小组（其中包括2名公众成员）来监督我们的工作。我们的工作成果以多种形式呈现，如科学和医学论文、讲座（包括公开讲座）以及新闻、广播和电视采访。

Prion diseases are fatal disorders that affect the brain, and include diseases such as BSE or ?mad cow disease? in cattle and CJD in humans. One form of CJD, known as variant CJD, is linked to exposure to BSE through the diet. Prion diseases are transmissible, and studies of CJD and BSE have shown that the infectious agent accumulates at highest levels in the brain. However, the agent can also be present in a range of other tissues throughout the body. The aim of this research is to continue the collection and storage of tissues from all forms of CJD in a bank in the National CJD Surveillance Unit, Edinburgh. This bank played a key role in the discovery of variant CJD, and is used by a wide range of researchers in UK and across the world. The material collected comes from tissue and organs taken at autopsy from patients with suspected CJD only when the relatives have given consent. We also collect blood samples from living patients, again with the consent of the relatives. The bank has approval for this work from our local Ethical Committee, and has been used for many research projects, resulting in major scientific and medical publications. The information from this research has also made a big impact on the work of the NHS, particularly in steps to reduce the chance of transmission of variant CJD by blood transfusion and by surgical instruments. We believe that the bank will continue to be needed by researchers in the UK and elsewhere in the future, since there are so many unanswered questions about this group of diseases. There is also a major need to help develop a test for CJD that can be used on living patients, which will be helped by the use of the tissue and blood samples in our bank. We run the bank according to MRC guidelines, and plan to use a MRC Steering Group (which includes 2 members of the public) to oversee our work. The results from our work are presented in many forms, such as scientific and medical papers, lectures (including public lectures) and in interviews with the press, radio and television.