Research Fellowship in Geriatric Mood Disorders

描述(由申请人提供)：这是T32康奈尔大学老年情绪障碍研究生研究奖学金项目的第四个竞争性申请，该项目提供多学科培训已有15年之久。从概念上讲，我们认为情绪障碍是异质性的，其病因来自遗传因素、衰老和疾病相关的生物变化、残疾和心理社会因素。在方法上，我们教授生物学评估技术以及纵向设计和临床驱动的干预措施，在患者和实践层面。这种方法导致了在有巨大健康和心理健康需求的人群中进行转译研究。 该计划的优势是：1.学员的优异学习成绩；过去10年的学员中，87%的学员在培训期间获得了竞争性的飞行员津贴，31%的毕业生获得了NIMH K奖。2.在翻译研究方面有成就的学院，研究范围包括分子生物学、遗传学、结构和功能神经成像、临床药理学、治疗效果和有效性研究，以及精神健康服务研究。3.在六个多中心研究中的领导力。4.康奈尔大学研究所统一组织培训和研究资源。5.丰富的实验室资源。6.关于老年精神病和内科病人以及社区的数据库，可供研究员进行二次分析。7.与老年医学、普通内科、临床流行病学和服务研究计划以及医学伦理学的研究人员长期有效地合作。 该计划将由临床生物学(G.Alexopoulos)和服务领域的资助研究人员指导 研究(M.Bruce)，在研究培训方面有良好的记录，并由在分子生物学、神经成像和治疗研究方面具有专业知识的执行委员会提供。我们要求每年支持3名学员，他们的个性化培训计划将由两名导师(例如，一名临床和一名基础研究员或一名服务和一名临床研究员)协调，以促进翻译研究。除了核心课程之外，我们还指导和支持学员进行他们自己的研究，准备有竞争力的资助申请，并发表基于数据的论文。

DESCRIPTION (provided by applicant): This is the fourth competing application of the T32 Cornell Postgraduate Research Fellowship Program in Geriatric Mood Disorders, which has been offering multidisciplinary training for 15 years. Conceptually, we view mood disorders as heterogeneous with etiological contributions from genetic factors, aging- and disease-related biological changes, disability, and psychosocial factors. Methodologically, we teach biological assessment techniques as well as longitudinal designs and clinically-driven interventions at the patient and the practice level. This approach has led to translational studies in a population with great health and mental health needs. The Program's strengths are: 1. The exceptional academic record of its trainees; 87% of the past 10 years' trainees received competitive pilot grants during their training and 31% of the graduates received NIMH K Awards. 2. An accomplished faculty in translational research with studies ranging from molecular biology, genetics, structural and functional neuroimaging, clinical pharmacology, treatment efficacy and effectiveness research, and mental health services research. 3. Leadership in six multicenter studies. 4. Cohesive organization of training and research resources by the Cornell ACISR. 5. Rich laboratory resources. 6. Databases on elderly psychiatric and medical patients and in the community available for secondary analyses by the fellows. 7. Long and effective collaboration with investigators of Geriatric Medicine, General Internal Medicine, Clinical Epidemiology and Services Research Program, and Medical Ethics. The Program will be directed by funded investigators in clinical biology (G. Alexopoulos) and services research (M. Bruce) with a strong record in research training and by an Executive Committee with expertise in molecular biology, neuroimaging, and treatment studies. We request support for 3 trainees per year, whose individualized training programs will be coordinated by two preceptors (e.g. one clinical and one basic investigator or one services and one clinical investigator) to facilitate translation research. Beyond a Core Curriculum, we guide and support our trainees in conducting their own research studies, in preparing competitive funding applications, and in publishing data-based papers.