Clinical Trials Network, Ohio Valley Node U10DA013732

描述（由申请人提供）：自2000年加入NIDA临床试验网络（CTN）以来，俄亥俄谷节点（OVN）一直是一个高效、热情、充满活力的节点，在提供科学和行政领导、与其他节点、NIDA和合同员工合作以及传播循证实践和CTN研究结果方面表现出色。OVN的社区治疗项目（CTPs）及其区域研究和培训中心（RRTC）共同努力创建了一个节点，CTN在研究人员和治疗提供者之间的双边交流/合作目标已经完全实现。成功地将这个地理上分散的节点的所有成员整合为一个统一的整体，加上节点PI、CTP PI和RRTC工作人员对充分参与CTN的坚定承诺，使OVN在其CYN成员期间具有极高的生产力。OVN有一批经验丰富的工作人员，包括几名自OVN成立以来一直在工作的RRTC和CTP pi。OVN继续与越来越多的ctp合作，这些ctp具有各种患者特征，并扩展到广泛的地理范围，目前包括整个中西部（12个州）以及肯塔基州、田纳西州和西弗吉尼亚州的上南部州。这23个OVN CTPs每年共接待超过10万名患者，将为CTN研究的潜在参与者的数量和种类做出重大贡献。OVN未来五年的行政和管理计划利用OVN的优势：经验、团队合作和不同领域的专业知识（包括艾滋病毒/艾滋病、急诊医学、将成瘾治疗纳入初级保健和远程医疗），因此OVN可以继续在制定/实施CTN协议方面发挥科学领导作用和卓越表现。OVN详细介绍了一项研究议程，旨在通过优化药物辅助治疗和扩大办公室阿片类药物治疗来改善阿片类药物依赖治疗。Node已经与四个成瘾技术和转移中心（attc）积极合作，这些中心与OVN覆盖的州有关，Node计划加强与其他网络的关系（例如辛辛那提临床与转化科学与培训中心）。

DESCRIPTION (provided by applicant): From the beginning of its membership in NIDA's Clinical Trials Network (CTN) in 2000, the Ohio Valley Node (OVN) has been an effective, enthusiastic, and energetic node that has excelled in providing scientific and administrative leadership, in collaborating with other nodes and with NIDA and contract staff, and in disseminating information about evidence-based practices and the results of CTN studies. The OVN's Community Treatment Programs (CTPs) and its Regional Research and Training Center (RRTC) have worked together to create a node in which the CTN's goal of bilateral communication/collaboration between researchers and treatment providers has been fully realized. The success in integrating all members of this geographically dispersed node into a unified whole, together with the strong commitment of the Node PI, CTP PIs, and RRTC staff to full participation in the CTN, have enabled the OVN to be extremely productive throughout its membership in the CYN. The OVN has an experienced staff, including several RRTC and CTP PIs who have been with the OVN since its formation. The OVN continues to collaborate with a growing number of CTPs which have a variety of patient characteristics and extend over a broad geographical range now encompassing the entire Midwest (12 states) and the Upper-South states of Kentucky, Tennessee, and West Virginia. The 23 OVN CTPs, which together receive more than 100,000 patient visits a year, will contribute significantly to the number and variety of potential participants for CTN studies. The OVN administrative and management plans for the next five years capitalize on the strengths of the OVN: experience, teamwork, and varied areas of expertise (including HIV/AIDS, emergency medicine, integration of addiction treatment into primary care, and telemedicine), so the OVN can continue to contribute scientific leadership and excellence in developing/conducting CTN protocols. The OVN has detailed a research agenda designed to improve opioid dependence treatment by optimizing medication-assisted treatment and expanding office-based opioid treatment. Already cooperating actively with the four Addiction Technology and Transfer Centers (ATTCs) associated with the states covered by the OVN, the Node plans to strengthen relationships with other networks (e.g., Cincinnati Center for Clinical & Translational Science & Training). PUBLIC HEALTH RELEVANCE: To further the goal of expanding substance abuse care and research into non-traditional settings, Ohio Valley Node Community Treatment Programs now include an HIV/AIDS clinic, two primary care centers, and two hospital emergency departments. The Ohio Valley Node's research agenda is designed to improve opioid dependence treatment by optimizing medication-assisted treatment and expanding office-based opioid treatment, including a new mechanism for dosing buprenorphine which would reduce diversion.