Urological Complications of Obesity and Diabetes

描述（由申请人提供）：糖尿病（DM）是一系列使人衰弱、代价高昂的疾病，可导致多种严重并发症以及过早死亡。糖尿病和肥胖影响所有下尿路（LUT）的功能和结构，包括膀胱、尿道和前列腺;并可导致并发症，如尿失禁、排空不良和性功能障碍。泌尿系统并发症在高达80%的糖尿病患者中发现，这一比例高于广泛认可的并发症，如神经病变和肾病。PI及其团队广泛研究了I型DM（T1 DM）的LUT症状，包括糖尿病膀胱功能障碍（DBD）的表征，前列腺生长以及啮齿动物模型蛋白质组水平的分子靶点鉴定。基于这些发现，并响应RFA-DK-10-001，我们建议成立凯斯西储大学肥胖和糖尿病泌尿系统并发症跨学科研究中心（UCOD）。该中心的成立将：a）使我们现有的跨学科合作正式化，与来自6个不同研究团队的研究人员建立合作关系; B）将我们的工作扩展到肥胖和2型糖尿病的研究; c）为奥布莱恩泌尿学研究中心未来提交的提案提供大量的初步数据，该研究中心专注于UCOD，这是影响我们国家的最常见的良性泌尿系统疾病之一。 拟议的中心将包括一个研究提案，将作为我们关于UCOD的跨学科工作的科学路线图;一个行政核心，将规划和实施中心的短期和长期目标;和一个创新的丰富计划，这将使我们能够分享我们对UCOD的工作与其他50名初级和建立调查，博士后（博士和医学博士）研究员和学生，并为两名研究学者的工作提供机构支持，他们将在我们中心度过12个月。CWRU UCOD中心得到了CWRU和区域科学界的大力支持，包括大克利夫兰糖尿病协会。这种支持水平将确保我们的中心成为良性泌尿系统疾病（IR-BU）跨学科研究的区域中心，这是RFA-DK-10-001的最终目标。 公共卫生相关性：糖尿病和肥胖症，目前在美国呈上升趋势，会导致严重的泌尿系统并发症对肥胖和糖尿病（UCOD）的泌尿系统并发症的跨学科研究将促进改善和创新的方法来治疗或预防UCOD，这是影响我们国家的一些最常见的良性泌尿系统疾病。

DESCRIPTION (provided by applicant): Diabetes mellitus (DM) is a spectrum of debilitating, costly diseases that can lead to multiple and serious complications, as well as premature death. Diabetes and obesity impact the function and structure of all the lower urinary tract (LUT) including bladder, urethral, and prostate; and can lead to complications such as urinary incontinence, poor emptying, and sexual dysfunction. Urologic complications are found in up to 80% of individuals diagnosed with DM, a higher rate than that of widely recognized complications such as neuropathy and nephropathy. The PIs and their teams have extensively studied LUT symptoms of type I DM (T1DM), including characterization of diabetic bladder dysfunction (DBD), prostate growth, and identification of molecular targets at the proteome level in the rodent models. Based on those findings and in response to RFA-DK-10-001, we propose to form the Case Western Reserve University Interdisciplinary Research Center on Urological Complications of Obesity and Diabetes (UCOD). The formation of the Center will: a) formalize our existing interdisciplinary collaboration with established investigators from 6 different research teams; b) expand our work into studies of obesity and type 2 DM; and c) produce high volume preliminary data for future submission of proposals for O'Brien Urology Research Center focusing on UCOD, as one of the most common Benign Urological Diseases affecting our nation. The proposed Center will consist of a research proposal that will function as the scientific road map for our interdisciplinary work on UCOD; an Administrative Core that will plan and implement the short and long term objectives of the Center; and an innovative Enrichment Program that would allow us to share our work on UCOD with 50 other junior and established investigators, post-doctoral (PhD and MD) fellows, and students and provide Institutional support for the work of two Research Scholars who would spend 12 months in our Center. The CWRU Center on UCOD is strongly supported by the CWRU and regional scientific community including the Diabetic Association of Greater Cleveland. This level of support will assure maturation of our Center into a regional Center of Interdisciplinary Research in Benign Urological Disease (IR-BU), the ultimate aim of the RFA-DK-10-001. PUBLIC HEALTH RELEVANCE: Diabetes and obesity, currently on the rise in the U.S., can lead to serious urologic complications. Interdisciplinary studies on the Urologic Complications of Obesity and Diabetes (UCOD) will foster improved and innovative approaches to treatment or prevention of UCOD, which are some of the most common benign urologic diseases affecting our nation.