Case Incubator and Multidisciplinary Urologic Research Groups (CIMURG) in Women's

描述（由申请人提供）：尿失禁、尿路感染、骨盆疼痛、肥胖和糖尿病的泌尿系统并发症以及其他下尿路疾病（“女性下尿路功能障碍[WLUTD]”）严重影响女性的生活质量，并可能成为美国医疗保健系统的主要负担。预计老年女性人口和肥胖个体的增长将导致未来几十年WLUTD的患病率显著增加。为了充分了解WLUTD的机制，并改善对数百万受影响妇女的护理，需要多学科研究团队。该提案旨在为来自不同科学和临床背景的对WLUTD感兴趣的初级教师建立一个指导计划。多学科泌尿外科研究小组案例孵化器（CIMURG）计划每年将招募1名MD和1名博士级学者，以开发一个可持续的系统，用于发展和保留多学科研究人员和研究团队，共同目标是促进对良性LUTD女性的理解，预防和治疗。CIMURG计划将包括教学，研讨会和指导的综合计划，以准备学者成功设计，实施和领导涉及多学科团队的临床和/或转化研究项目，并获得独立资助。主要研究者是一名外科医生科学家，在WLUTD和泌尿外科培训方面有着悠久的NIH资助研究历史。此外，CIMURG计划还包括来自14个不同部门的24位杰出的基础科学，转化，临床和技术导师。CIMURG学者将有一个主要的临床和基础科学导师，一个来自转化科学学科的二级导师和一个技术导师。这种结合的指导方法将确保指导关系，重点是发展必要的技能，将基本或行为泌尿学研究结果从板凳上翻译到床边，到社区。这包括对科学方法的理解和工作知识，特别是假设发展，实验设计，统计方法和负责任的研究行为。总之，凯斯西储泌尿外科是最大的，组织良好的医学研究中心之一的成员，拥有丰富的资源，并有能力和愿望，通过拟议的CIMURG计划，支持在WLUTD多学科研究中有竞争力的新研究人员的职业发展。

DESCRIPTION (provided by applicant): Urinary incontinence, urinary tract infections, pelvic pain, urological complications of obesity and diabetes, and other disorders of the lower urinary tract ("women's lower urinary tract dysfunction [WLUTD]) severely impact a woman's quality of life and can be a major burden to the U.S. Healthcare system. It is anticipated that growth in the elderly female population and individuals with obesity, will lead to a significantly increased prevalence of WLUTD over the next few decades. To fully understand the mechanisms of WLUTD and to improve care for the millions of affected women, multidisciplinary research teams are required. This proposal seeks to establish a mentoring program for junior faculty from diverse scientific and clinical backgrounds with an interest in WLUTD. The Case Incubator for Multidisciplinary Urologic Research Groups (CIMURG) program will recruit 1 MD- and 1 PhD-level Scholars annually to develop a sustainable system for the development and retention of multidisciplinary researchers and research teams with a common goal of advancing the understanding, prevention and treatment of women with benign LUTD. The CIMURG program will include an integrated program of didactics, seminars and mentoring to prepare Scholars for successful design, implementation, and leadership of clinical and/or translational research projects involving multidisciplinary teams AND receipt of independent funding. The principal investigator is a surgeon scientist with a long history of NIH funded research in WLUTD and urological training. In addition, CIMURG program includes 24 outstanding basic science, translational, clinical, and technology mentors from 14 different departments. CIMURG Scholars will have a primary Clinical and a Basic Science mentor, a secondary mentor from a translational science discipline and a Technology Mentor. This combined mentoring approach will ensure a mentoring relationship that focuses on developing the skills necessary for translating basic or behavioral urologic research findings from bench to bedside, to community. This includes an understanding and working knowledge of the scientific method, particularly hypothesis development, experimental design, statistical methods, and the responsible conduct of research. In summary, Case Western Reserve Urology is a member of one of the largest, well- organized medical research centers with vast resources and has both the capabilities and the desire to support the career development of competitive new investigators in multidisciplinary research in WLUTD through the proposed CIMURG program.