Case Urology Translational Research Training Program (CUTRTP)

泌尿外科案例转化研究培训计划 (CUTRTP)

• 批准号: 8267771
• 负责人: Firouz Daneshgari
• 金额: $ 12.78万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267771
• 关键词: Research Training; Training Programs; Translational Research; Urology

DESCRIPTION (provided by applicant): Urological diseases which include conditions of the genito-urinary tract (GU) can be congenital or acquired, malignant or benign, and medical or surgical. Roughly more than 25 million visits to physicians and hospitals took place in 2000 for just the top 4 urologic conditions; however, the research portfolio to address them lags. Most experts would consider the shortage of qualified scientists and urologists-scientists as the most important contributing factor. Thus, the Urology Institute of the Case Western Reserve University (CWRU) Medical Center (CWRU UI) was created with the overarching goal of rapid expansion of translational research and training of a new generation of scientists and surgeon-scientists. Through the funding requested in this proposal we propose to establish the CWRU Urology Translational Research Training Program (CUTRTP), to expand our current support for the training of 2 to 6 postdoctoral PhD or postgraduate MDs, per year (12 total over 5-years), in two tracks of scientists (for Ph.D. or M.D. candidates) and surgeon-scientists (for MD Candidates). All candidates must have a strong desire to pursue a career in academic medicine focusing on translational research. The ideal successful PhD candidates will have completed their training and potentially, 0-1 years of postdoctoral work. The ideal successful MD candidates will have received their MD and completed residency in urology, gynecology, or family medicine at an ACGME accredited program, and have a history of research. The CUTRTP is based on 3 training pillars: 1) a translational focus for trainees with basic and clinica mentors to yield greater impact on improved patient care and outcomes 2) recruitment of the top researchers from other fields at CWRU as trainers of future investigators, 3) didactic and professional training, with milestones, evaluated by an independent Evaluation Committee. Using a structured curriculum, we propose to train a group of scientists and surgeon-scientists to focus on translational urology research in 3 main areas: a) genitourinary cancers, b) female pelvic floor disorders, and c) urological complications of obesity and diabetes. All trainees will receive the same level and commitment of mentoring throughout their 2 years of devoted research and must compete for the 2nd year position with other qualified trainees. A group of 29 outstanding trainers from 15 departments with a cumulative NIH-funding total of approximately $30 million have come together in the CUTRTP to ensure selection, recruitment, training, and delivery of some of the best scientists and surgeon-scientists in urological diseases. PUBLIC HEALTH RELEVANCE: Urological diseases may be life-threatening (including kidney and prostate cancers) or cause severe deterioration in quality of life (including urinary incontinence). As the U.S. population ages, these conditions will likely cause an even greater burden to patients and the healthcare system. This proposal would ensure training and development of new highly-qualified scientists and surgeon-scientists to ensure continued research into new treatment strategies for urological diseases using a bench to bedside approach to ultimately improve patient care.

描述（由申请人提供）：包括泌尿生殖道（GU）病症的泌尿系统疾病可以是先天性或后天性、恶性或良性、内科或外科疾病。 2000 年，仅前 4 种泌尿系统疾病就诊医生和医院的人数就超过 2500 万人次；然而，解决这些问题的研究组合却滞后。大多数专家认为缺乏合格的科学家和泌尿科医生科学家是最重要的影响因素。因此，凯斯西储大学 (CWRU) 医学中心泌尿外科研究所 (CWRU UI) 的总体目标是快速扩展转化研究并培训新一代科学家和外科医生科学家。通过本提案中要求的资金，我们建议建立 CWRU 泌尿学转化研究培训计划 (CUTRTP)，以扩大我们目前对每年 2 至 6 名博士后博士或研究生 MD 培训的支持（5 年内总共 12 名），分为科学家（针对博士或医学博士候选人）和外科医生科学家（针对医学博士候选人）两个轨道。所有候选人都必须有强烈的愿望从事以转化研究为重点的学术医学职业。理想的成功博士候选人将完成培训并可能完成 0-1 年的博士后工作。理想的成功医学博士候选人将获得医学博士学位，并在 ACGME 认可的项目中完成泌尿科、妇科或家庭医学的住院医师培训，并拥有研究历史。 CUTRTP 基于 3 个培训支柱：1) 为受训者提供转化重点，并配备基础和临床导师，以对改善患者护理和结果产生更大影响；2) 从 CWRU 招募其他领域的顶尖研究人员作为未来研究人员的培训师；3) 具有里程碑意义的教学和专业培训，由独立评估委员会进行评估。我们建议利用结构化课程，培训一批科学家和外科医生科学家，专注于 3 个主要领域的转化泌尿学研究：a) 泌尿生殖系统癌症，b) 女性盆底疾病，以及 c) 肥胖和糖尿病的泌尿系统并发症。所有学员在两年的专注研究中都将获得同等水平和承诺的指导，并且必须与其他合格的学员竞争第二年的职位。 CUTRTP 汇集了来自 15 个部门的 29 名优秀培训师，NIH 累计资助总额约为 3000 万美元，以确保选拔、招聘、培训和输送泌尿外科疾病领域最优秀的科学家和外科医生科学家。 公共卫生相关性：泌尿系统疾病可能危及生命（包括肾癌和前列腺癌）或导致生活质量严重恶化（包括尿失禁）。随着美国人口老龄化，这些情况可能会给患者和医疗保健系统带来更大的负担。该提案将确保培训和培养新的高素质科学家和外科医生科学家，以确保利用从工作台到床边的方法继续研究泌尿系统疾病的新治疗策略，最终改善患者护理。