Histopathology

历史学核心将为所有3个项目提供整体支持。这个核心将集中 PPG所有项目的病理学资源。这将节省成本，提高质量 项目结果之间的控制和最大可比性。 核心的主要功能包括：1）在实验设计的免疫组织学方面提供专家建议， 优化结果; 2）均匀的组织处理; 3）组织切片（冷冻切片和石蜡包埋 切片）; 4）组织切片的组织化学和免疫组织化学染色; 5）病理切片 裂隙切片的解释; 6）通过高质量的数字显微镜记录病理学 摄影; 7）为手稿准备数字; 8）存储和检索染色的幻灯片， 项目。 此外，该核心将负责所有抗体的订购、质量保证和控制研究 和用于病理学方法的试剂。新试剂将被开发和评估， 三个项目的调查人员提出的要求。

The Histopathology Core will provide integral support for all 3 projects. This core will centralize the pathology resources for all of the projects of the PPG. This will result in cost savings, increased quality control and maximal comparability between the results of the projects. Key funcfions of the Core include: 1) expert advise in immunohistological aspects of experimental design to optimize results; 2) uniform tissue processing; 3) tissue secfioning (frozen sections and paraffin-embedded sections); 4) histochemical and immunohistochemical staining of tissue secfions; 5) pathological interpretation of fissue sections; 6) documentafion of the pathology by high quality digital microscopic photography; 7) preparation of figures for manuscripts; 8) storage and retrieval of stained slides for each of the projects. In addifion, this Core will be responsible for ordering, quality assurance and control studies of all anfibodies and reagents for use in the pathology methods. New reagents will be developed and evealuated as requested by investigators in the 3 projects.