Identifying early molecular changes underlying familial Alzheimer’s disease

利用先进的分子、计算和行为技术对我们独特的遗传性家族性阿尔茨海默病（fAD）遗传模型进行分析，揭示了早在疾病发生之前，大脑功能就发生了巨大的早期变化。我们将扩展我们的工作，将我们的第一个模型与来自哥伦比亚的最常见的fAD突变E280A“Paisa”模型进行比较。这些模型之间的共性将帮助我们确定导致阿尔茨海默病的初始压力。

Analysis of our unique genetic model of inherited, familial Alzheimer’s disease (fAD) using advanced molecular, computational and behavioural techniques is revealing dramatic, early changes in brain function long before the disease would occur. We will expand our work to compare our first model with a model of the most common fAD mutation E280A “Paisa” from Columbia. Commonalities between the models will help us identify the initial stresses that cause Alzheimer’s disease.