Mutagenesis 2008 Gordon Research Conference

描述（由申请人提供）：突变启动并促进多种人类疾病的进展，特别是癌症和神经退行性疾病；DNA损伤的诱变修复有助于衰老。2008年戈登诱变研究会议将集中讨论引起基因组不稳定的诱变的分子机制。本次会议的目标是：(1)探索突变机制的现有知识；（二）确定新的调查途径；(3)确定维持基因组完整性的治疗策略；(4)促进合作；(5)促进这一关键研究领域的长期发展。该计划将特别侧重于提供维持人类基因组完整性的途径的机制理解的进展，重点是这些途径如何交叉遗传疾病，癌症，神经变性和衰老。八场会议将讨论：(i)由于复制和转录阻断引起的突变，（ii）氧化应激的后果，（iii）重组引起的基因组不稳定，（iv）免疫反应中的生理突变，(v)与基因组不稳定、神经变性和早衰相关的罕见人类疾病，（vi）低保真复制和癌症，（vii）诱变机制，以及（viii）错配修复：最终的保真检查。分子和机制强调在各种生物环境中至关重要的途径，旨在吸引独特的研究人员，并推动他们未来的研究。

DESCRIPTION (provided by applicant): Mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases; and mutagenic repair of DNA damage contributes to aging. The 2008 Gordon Research Conference on Mutagenesis will focus on the molecular mechanisms of mutagenesis that give rise to genomic instability. The goals of this meeting are (1) to explore current knowledge of mutagenesis mechanisms; (2) to identify new avenues of investigation; (3) to define therapeutic strategies for maintenance of genomic integrity; (4) to stimulate collaborations; and (5) to foster the long-term development of this critical research area. The program will specifically focus on advances that provide mechanistic understanding of pathways that maintain the integrity of the human genome, with emphasis on how these pathways intersect genetic disease, cancer, neurodegeneration and aging. The eight sessions will consider: (i) Mutagenesis Due to Blocked Replication and Transcription, (ii) Consequences of Oxidative Stress, (iii) Recombination Induced Genomic Instability, (iv) Physiological Mutagenesis in the Immune Response, (v) Rare Human Diseases Associated with Genomic Instability, Neurodegeneration and Premature Aging, (vi) Low-fidelity Replication and Cancer, (vii) Mechanisms of Mutagenesis, and (viii) Mismatch Repair: the Final Fidelity Check. The molecular and mechanistic emphasis on pathways critical in a variety of biological contexts is designed to attract a unique audience of researchers and propel their future research.