COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 COBRE中心的最初目标之一是创建一个翻译核心：（a）促进基础和临床神经科学家之间的互动，以加强翻译研究，（B）支持本科生，医学生和居民的研究经验。 在2003年，我们发起了一个深入的本科生暑期研究经验，暑期神经科学本科研究奖学金计划。 翻译中心每年的主要职责是组织和介绍一门教学课程，重点是特定的神经疾病或精神疾病。 该课程旨在说明转化神经科学研究的进展，重点是特定的疾病实体。 所承保的疾病每年都在变化。 在以前的赠款期间，所涵盖的疾病实体包括帕金森病，多发性硬化症，精神分裂症，肌萎缩性侧索硬化症和脑血管疾病。 在过去的一年里，该课程的重点是自闭症，包括12个每周一次的会议，从临床研究到基础分子方法。 来自神经病学，神经外科，心理学，医学和解剖学与神经生物学系的教师在这个团队授课的课程中合作。 此外，两名外部演讲者Eric Fombonne博士（麦吉尔大学）和John Constantino博士（华盛顿大学）在过去一年也提供了讲座。 该课程由研究生，居民和教师参加。 在未来一年，该课程将侧重于老年人痴呆症。 在过去的资助期间，没有医学生选择通过翻译核心全年医学研究计划获得研究经验，尽管该计划做了很好的宣传。 我们将继续努力，积极招募二年级医学生为这个研究机会下一个赠款年度。 夏季本科神经科学研究奖学金（SNURF）计划继续非常成功。 自成立以来，每年有8名学生参加这个夏季研究计划。 我们已经能够吸引来自全国各地的学生，并包括年轻妇女和学生从代表性不足的群体每年。 基础和临床神经科学教师作为学生导师参与，不同神经科学教师之间的互动的副作用是提高了转化研究活动。 本科生进行10周的研究，阅读主要文献，并参加COBRE教师的讲座。 超过160名学生（大部分来自UVM以外的机构）申请了今年SNURF计划的职位，该计划将于5月底开始。 8名学生被录取。 这些学生是由四名教师组成的招生委员会（Eckenstein，May，Nishi和Spees博士）在评估他们的申请后选出的。 所有的录取委员会成员都与神经科学COBRE有关。 这8名学生将获得神经科学COBRE支持的3，500美元的津贴，今年，与往年一样，根据现有资金，我们将尝试从当前的COBRE补助金或各种部门资源中提供支持，以帮助支付他们的住房费用。 此外，佛蒙特大学今年还为三名代表性不足的少数民族学生提供了助学金。 我们最近开始在学生从暑期研究项目毕业后定期与他们联系，以监测他们的职业发展和我们在帮助他们方面的有效性。 在该计划已经存在的六年中，大多数过去的参与者已经进入医学或研究生院，其中包括两名目前正在我们的神经科学研究生课程的学生。 其他人选择从学校抽出时间接受技术职位，其中两人在UVM。 我们很高兴在这里获得的经验，大大帮助了我们过去的许多学生在他们的专业发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the original goals of the COBRE Center was the creation of a Translational Core to: (a) facilitate interactions between basic and clinical neuroscientists to enhance translational research, and (b) support research experiences for undergraduate students, medical students and residents. In 2003, we initiated an in-depth summer research experience for undergraduate students, the Summer Neuroscience Undergraduate Research Fellowship Program. A major responsibility of the Translational Core each year is to organize and present a didactic course, which focuses on a specific neurological disease or psychiatric disease. The course is designed to illustrate the progress of translational neuroscience research, which is focused on a particular disease entity. The disease to be covered changes every year. In prior grant periods, the disease entities covered included Parkinson's Disease, Multiple Sclerosis, Schizophrenia, Amyotrophic Lateral Sclerosis and Cerebrovascular Diseases. This past year, the course focused on Autism and consisted of 12 weekly sessions ranging from clinical research to basic molecular approaches. Faculty from the Departments of Neurology, Neurosurgery, Psychology, Medicine and Anatomy & Neurobiology collaborate in this team-taught course. In addition, two outside speakers, Drs. Eric Fombonne (McGill University) and John Constantino (Washington University) contributed lectures this past year. The course is attended by graduate students, residents and faculty. In the upcoming year, the course will focus on Dementias of the Elderly. During this past grant period, no medical students elected to gain research experience through the Translational Core year-out medical research program even though the program was well advertised. We will continue efforts to actively recruit second year medical students for this research opportunity next grant year. The Summer Undergraduate Neuroscience Research Fellowship (SNURF) program continues to be very successful. Since its inception, 8 students have participated in this summer research program each year. We have been able to attract students from across the country and have included young women and students from underrepresented groups each year. Both basic and clinical neuroscience faculty participate as student mentors and a side effect of the interaction of different neuroscience faculty has been an enhancement of translational research activities. Undergraduates perform 10 weeks of research, read primary literature and attend lectures given by COBRE faculty. Over 160 students (most from institutions outside of UVM) applied for positions in this year's SNURF program, which will start at the end of May. Eight students were accepted. These students were selected by an admissions committee of four faculty members (Drs. Eckenstein, May, Nishi and Spees) after evaluating their applications. All of the Admission Committee Members are associated with the Neuroscience COBRE. The 8 students will receive a stipend of $3,500 supported by the Neuroscience COBRE and this year, as in previous years and based on available funding, we will try to provide support from the current COBRE grant or from a variety of departmental resources to help defray their housing costs. In addition, the University of Vermont has provided stipends for three underrepresented minority students this year. We have recently begun to contact students periodically after they graduate from the summer research program in order to monitor their career development and our effectiveness in assisting them. In the six years the program has been in existence, the majority of past participants have gone on to medical or graduate school, including two who are currently students in our Neuroscience Graduate Program. Others have elected to take time out from their schooling to accept technical positions, two at UVM. We are pleased that the experience gained here has significantly helped many of our past students in their professional development.