Center for Neuroscience Excellence

描述（由申请人提供）：此申请代表了佛蒙特大学（UVM）神经科学生物医学研究卓越中心（COBRE）支持的竞争性更新。该提案的具体目标是：具体目标1：进一步发展弗吉尼亚大学神经科学卓越中心的研究和智力基础设施。这一宗旨的目标包括1)继续为初级神经科学教师提供指导计划，2)维持成像/生理学核心和细胞/分子核心，以支持神经科学社区的研究项目，3)支持全校范围的神经科学系列研讨会和年度务静会，4)促进基础和临床科学家之间的对话，促进合作和转化研究的发展。具体目标2：支持将成为神经科学卓越中心未来领导者的初级教师核心小组的研究发展。他们的研究项目包括：1)Alan Howe博士：生长体引导过程中蛋白激酶A信号的空间调控；2)Miguel Martin-Caraballo博士：GluR2 AMPA受体亚基表达的发育调控；3)Jeffrey Spees博士：成体骨髓干细胞对CMS的修复；4)Umadevi Wesley博士：二肽基肽酶IV （DPPIV）在周围神经发生和神经母细胞瘤中的作用。UVM在分子/发育，细胞/系统和临床/行为神经科学方面建立了研究人员。目前的COBRE在神经科学领域提供了一个非常成功的机制，以显着扩大这些现有领域的研究实力，将基础与临床神经科学相结合，为初级教师创建长期指导框架，并开发一个新的全校范围的神经科学研究生课程。下一个拨款周期的目标是在我们成功的基础上，发展一支由有才华的初级和高级研究人员组成的有凝聚力的团队，专注于神经元的发育和分化，这将成为未来预防和治疗神经系统疾病策略应用的核心。由于其税基不足625,000人，UVM是该州唯一一个资源有限的博士学位授予机构。目前的COBRE资金在开发优秀的神经科学研究基础设施方面发挥了重要作用，这使得UVM神经科学界能够成功地竞争重要的新机构资金和外部支持。国家研究资源中心在下一个资助周期继续支持神经科学COBRE，将确保投资回报，这将有利于大学、佛蒙特州、国家研究企业和寻求科学答案和希望的患者。

DESCRIPTION (provided by applicant): This application represents the competitive renewal for support of the Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM). Specific aims of this proposal are: Specific Aim 1: Further develop the research and intellectual infrastructure of the University-wide Center for Neuroscience Excellence at UVM. Goals of this aim include 1) to continue a mentoring program for junior neuroscience faculty, 2) to maintain an imaging/physiology Core and a cellular/molecular Core to support the research projects of the neuroscience community, 3) to support a University-wide Neuroscience Seminar Series and Annual Retreat, and 4) to facilitate dialogue between basic and clinical scientists that promotes development of collaborative and translational research. Specific Aim 2: Support the research development of a Core group of junior faculty who will be future leaders in the Center for Neuroscience Excellence. The faculty and their project titles are 1) Dr. Alan Howe: Spatial Regulation of Protein Kinase A Signaling During Growth Cone Guidance, 2) Dr. Miguel Martin-Caraballo: Developmental regulation of GluR2 AMPA receptor subunit expression, 3) Dr. Jeffrey Spees: Adult Bone Marrow Stem Cells For CMS Repair, and 4) Dr. Umadevi Wesley: Role of Dipeptidyl Peptidase IV (DPPIV) in Peripheral Neurogenesis and Neuroblastomas. UVM has established investigators in molecular/developmental, cellular/systems and clinical/behavioral neuroscience. The current COBRE in Neuroscience provided a highly successful mechanism to significantly expand research strength in these existing areas, to integrate basic with clinical neuroscience, to create a long term mentoring framework for junior faculty and to develop a new university-wide Neuroscience Graduate Program. A goal of the next grant cycle is to build upon our success and develop a cohesive group of talented junior and senior investigators focused on neuronal development and differentiation that will form the Core for future applications directed at strategies to prevent and treat neurologic disease. UVM is the only doctoral degree granting institution in a state with limited resources due to its tax base of fewer than 625,000 people. The current COBRE funding has been instrumental in developing an excellent research infrastructure for neuroscience that has allowed the UVM neuroscience community to compete successfully for both significant new institutional funds and extramural support. Continued support of the Neuroscience COBRE by the National Center for Research Resources over the next funding cycle will ensure a return on investment that will benefit the University, the State of Vermont, the national research enterprise, and the patients looking to science for answers and hope.