Yoga and Cardiovascular Disease Risk in Older Women

描述（由申请人提供）：心血管疾病（CVD）仍然是妇女死亡的主要原因。心血管疾病的风险随着绝经期急剧上升，并且在患有2型糖尿病（DM 2）的女性中进一步升高。这些增加可能是由于胰岛素抵抗和其他相关的动脉粥样硬化变化同时增加，包括胰岛素抵抗综合征（IRS）。越来越多的证据表明，瑜伽练习可能为糖尿病和非糖尿病人群减少心血管疾病irs相关风险因素提供了一种安全且经济有效的策略。然而，严谨的研究很少。拟议的K-01奖将为Kim Innes博士提供必要的培训、技能和经验，Kim Innes博士是一位在女性健康和慢性病方面有很强背景的流行病学家，最近在CAM方面接受了奖学金培训，以开展关于瑜伽对降低女性心血管疾病风险的影响的临床干预研究。她的长期目标是建立一个成功的研究项目

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) remains the leading cause of death in women. CVD risk rises sharply with menopause and is further elevated among women with type 2 diabetes (DM 2). These increases are likely due to the coincident rise in insulin resistance and other, related atherogenic changes comprising the insulin resistance syndrome (IRS). There is growing evidence that the practice of yoga may offer a safe and cost-effective strategy for reducing IRS-related risk factors for CVD in both diabetic and non-diabetic populations. However, rigorous studies are few. The proposed K-01 award will provide the necessary training, skills, and experience for Dr. Kim Innes, an epidemiologist with a strong background in women's health and chronic disease and recent fellowship training in CAM, to conduct clinical intervention research regarding the effects of yoga on CVD risk reduction in women. Her long-term goal is to establish a successful research program investigating yoga for the prevention and management of CVD and related chronic, insulin resistance conditions. Immediate goals toward this end are, through a rigorous program of didactic training and research, to: 1) gain additional expertise in advanced quantitative methods, chronic disease physiology, and stress biology; 2) develop a solid practical and theoretical background in the field of mind-body and behavioral medicine, with a focus on yoga therapy; and 3) strengthen her skills in clinical intervention research and gain needed experience in behavioral intervention studies involving mind-body therapies. The candidate has assembled an exceptional sponsoring committee of investigators with extensive expertise in each of these disciplines, who will guide her activities and progress throughout the award period. The training program will include regular meetings with the lead sponsor and co-sponsors, coupled with participation in selected courses, tutorials, workshops, seminars, professional meetings and research practica relevant to Dr. lnnes's area of research. Dr. Innes will execute two pilot studies that will comprise the focus of the K award and the basis for at least two subsequent RO1 grant applications to be submitted within the award period. Using a randomized controlled design, these pilot studies will investigate the effects of a gentle 8-week lyengar yoga program on insulin sensitivity and related metabolic and psychological indices of CVD risk in two populations at elevated risk for CVD: sedentary, overweight postmenopausal women who are currently healthy and postmenopausal women with DM 2. The proposed studies will yield important information on the potential utility of a safe, inexpensive intervention in reducing CVD risk in both diabetic and healthy women postmenopause. If findings are positive and confirmed in other, larger studies, the use of yoga as a therapeutic intervention and prevention measure for CVD and related comorbidities could potentially save billions of dollars in health care costs and lost productivity due to these disorders.