Spore in Head and Neck Cancer

描述(由申请者提供)：本申请为约翰霍普金斯大学医学院在头颈癌方面的卓越研究(孢子)专业计划的继续申请，该计划支持一个高度互动、多学科和跨机构的计划。我们提出了五个研究项目、三个核心、一个职业发展和一个研究发展计划，以开展我们的头颈癌转化性研究。 研究项目1--肿瘤抑制基因启动子高甲基化用于检测头颈癌--共同研究人员David Sidransky(基础)和Joseph Califano(临床)。研究项目2-hNSC的分子筛查和风险预测。-联合调查员，William Westra(基础)和Wayne Koch(诊所)。研究项目#3-头颈部鳞状细胞癌(HNSC)的HPV疫苗治疗和应答的相关性--共同研究人员，TC Wu(基础)和Sara Pai(临床)。研究项目#4--头颈部癌症的联合治疗--评估EGFR/TK途径的抑制剂--共同研究人员Manuel Hidalgo(基础)和Arlene Forastiere(临床)。研究项目#5-开发用于治疗甲状腺癌的RET抑制剂--合作研究人员，Barry Nelkin(基础)和Doug Ball(临床)。 这些核心支持研究计划(核心#1-病理学/组织核心，Westra博士；核心#2-行政/临床核心(Dr.Sidransky&Forastiere)；核心#3-生物统计学和生物信息学核心(Dr.Goodman))。 职业发展计划(Forastiere博士)帮助新的研究人员的出现，研究发展计划(David Sidransky博士)为创新方向提供快速资金。

DESCRIPTION (provided by applicant): This application for continuation of the Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer at the Johns Hopkins University School of Medicine supports a highly interactive, multidisciplinary, and inter institutional program. Five research projects, three cores, a career development and a research developmental program are proposed to carry out our translational research in head and neck cancer. Research Project #1- Tumor Suppressor Gene Promoter Hypermethylation for Detection of Head and Neck Cancer - Co-Investigators, David Sidransky (basic) and Joseph Califano (clinic). Research Project #2 - Molecular Screening and Risk Prediction of HNSC. - Co-Investigators, William Westra (basic) and Wayne Koch (clinic). Research Project #3 - HPV Vaccine Therapy and Correlates of Response in Head and Neck Squamous Cell Carcinomas (HNSC) - Co-Investigators, TC Wu (basic) and Sara Pai (clinic). Research Project #4 - Combined Modality Treatment of Head and Neck Cancer Evaluating Inhibitors of the EGFR/TK Pathway - Co-Investigators, Manuel Hidalgo (basic) and Arlene Forastiere (clinic). Research Project #5 - Exploitation of RET Inhibitors for Treatment of Thyroid Cancer - Co-Investigators, Barry Nelkin (basic) and Doug Ball (clinic). The cores support the research programs (Core #1 - Pathology/ Tissue Core, Dr. Westra; and Core #2 - Administrative/Clinical Core (Drs. Sidransky & Forastiere), Core #3 - Biostatistics and Bioinformatics Core (Dr. Goodman). The Career Development Program (Dr. Forastiere) aids the emergence of new investigators and the Research Developmental Program (Dr. David Sidransky) provides rapid funding of innovative directions.