Pathology and Tissue Core

有效的组织采购和利用对于有意义的翻译研究活动至关重要。这个 组织采购和血液病理学核心将与每个孢子项目和生物统计一起工作 和数据管理核心，以确保高效和高度协调的采购、使用和存储 血液和骨髓样本。该中心将获取和维护一个血液样本储存库(包括 外周血、骨髓活检和骨髓抽吸物)，用于实验室，有效 所有实验室样本的编码系统，以确保患者的机密性和防止实验偏见。 调查人员、研究护士、生物统计学家和 血液病理学家以及活动的标准化操作程序将提供最佳组织 收集和准确处理、分析和储存每个样品。因此， 病理学和组织核心是促进临床的获取、保存、分析和分散 并为所有项目调查人员提供血液病理学特征和标本。 组织采购和血液病理学核心有以下目标： ？建立和维护血液和骨髓样本的储存库，包括完整的细胞， 白血病和MDS患者的血清、细胞DNA、RNA和蛋白质(包括 新诊断、缓解和/或复发)在M.D.安德森接受护理或评估 癌症中心。将组织标本分发给孢子调查员进行分析并提供 在孢子项目中对组织切片进行的研究的解释专业知识提供 孢子项目中使用的血液和骨髓样本的全面组织学特征， 包括来自进入临床方案的患者的样本。 ？向孢子研究人员提供现货和定制的反相蛋白质阵列。 维护包含详细临床和病理数据的全面、前瞻性交互数据库 适用于在M.D.安德森癌症中心接受护理或评估的白血病和MDS患者 ？通过共享血液和骨髓资源，促进孢子间的合作。 摘要：有效的组织获取和利用对有意义的翻译研究至关重要 活动。组织采购和血液病理学核心将与每个孢子项目和 生物统计和数据管理核心，以确保高效和高度协调的采购、使用和 血液及骨髓样本的储存

Effective tissue procurement and utilization is vital for meaningful translational research activities. The Tissue Procurement and Hematopathology Core will work with each SPORE project and the Biostatistics and Data Management Core to ensure efficient and highly-coordinated procurement, use and storage of blood and bone marrow samples. The Core will obtain and maintain a repository of blood samples (including peripheral blood, bone marrow biopsies, and bone marrow aspirates) for laboratory use, with an effective coding system for all laboratory specimens to ensure patient confidentiality and prevent experimental bias. Continuous communication between the investigators, research nurses, biostatisticians and hematopathologists, as well as standardized operating procedures for activities will provide for optimal tissue collection and accurate processing, analysis and storage of each sample. Thus, the functions of the Pathology and Tissue Core are to facilitate acquisition, preservation, analysis and dispersal of clinical samples and to provide hematopathologic characterization and specimens for all project investigators. The Tissue Procurement and Hematopathology Core has the following objectives: ¿ Develop and maintain a repository of blood and bone marrow specimens, including intact cells, serum, cellular DNA, RNA and protein, from patients with leukemia and MDS (including patients who are newly diagnosed, in remission and/or in relapse) receiving care or evaluation at M.D. Anderson Cancer Center. Distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Provide comprehensive histologic characterization of blood and marrow samples used in SPORE projects, including specimens from patients entered onto clinical protocols. ¿ Provide stock and customized Reverse Phase Protein Arrays to Spore researchers. ¿ Maintain a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with leukemia and MDS receiving care or evaluation at M.D. Anderson Cancer Center ¿ Facilitate inter-SPORE collaborations through sharing of blood and marrow resources. Lay Abstract: Effective tissue procurement and utilization is vital for meaningful translational research activities. The Tissue Procurement and Hematopathology Core will work with each SPORE project and the Biostatistics and Data Management Core to ensure efficient and highly-coordinated procurement, use and storage of blood and bone marrow samples