Clinical and Basic Studies in Male Reproduction

该提案旨在增加我们对生殖生物学的知识和理解， 药在男性。这是基础科学家和临床医学家之间的多学科协作努力。 研究人员，他们致力于促进我们对生殖生理学的理解， 将这些知识用于改善人类健康和福祉。建议的目标包括三个主要方面 生殖轴的分支下丘脑垂体和睾丸拟议的研究包括 基础和临床研究，这些研究与理解某些疾病有直接关系， 人类生殖，包括特发性低促性腺激素性腺功能减退症，雄激素不敏感综合征， 减数分裂停滞、仅支持细胞综合征和少精子症或无精子症。我们的临床项目 了解荷尔蒙和遗传环境所需的功能意义， 男性精子发生基础科学计划研究促性腺激素的神经内分泌控制 分泌，血睾屏障的分子基础，以及调节睾丸分泌的关键信号通路。 成熟配子的发育和功能。每个项目都涉及至少一个其他的合作， 中心，分子生理学与临床研究相结合。我们相信这 这一方法将提供最佳机会，为开发改进的 治疗某些生殖疾病的疗法，并作为发展更好的 男性荷尔蒙避孕的选择。 我们致力于科学卓越和跨学科的交流，从分子生物学到生物学。 从生物学到生理学和医学。我们的提案结合了杰出调查员的才能， 其经验和知识代表了生殖生物学及其 与人类健康的相关性。我们特意组织了该中心，以汇集最好的， 华盛顿大学的生殖生物学家和医学科学家在一个科学的 协作我们期待着继续参与NIH专业合作中心 生殖研究计划（SCCPRR）。我们的共同目标是促进沟通，创新， 和卓越的研究，最终目标是通过加速发展，改善人类生殖健康。 将实验室发现转化为临床实践。我们致力于合作精神， SCCPRR，并与其他几个国家的SCCPRR项目的研究人员建立了合作关系。 机构职能体系我们期待着为这一重要领域的杰出临床和基础研究做出贡献。 国家方案。

This proposal is designed to increase our knowledge and understanding of reproductive biology and medicine in the male. This is a multidisciplinary and collaborative effort among basic scientists and clinical investigators, who are committed to advancing our understanding of reproductive physiology and translate this knowledge into improving human health and well-being. The proposed aims comprise the three major branches of the reproductive axis? the hypothalamus, pituitary and testis. The proposed research embraces both basic and clinical investigations, which have direct relevance to understanding certain disorders of human reproduction, including idiopathic hypogonadotropic hypogonadism, androgen insensitivity syndrome, meiotic arrest, Sertoli cell only syndrome, and oligospermia or azoospermia. Our clinical project is focused on understanding the functional significance of the hormonal and genetic environment required for spermatogenesis in men. The basic science projects investigate the neuroendocrine control of gonadotropin secretion, the molecular basis of the blood-testis barrier, and the key signaling pathways that regulate the development and function of mature gametes. Each project involves a collaboration with at least one other in the Center, and the molecular physiology is integrated with the clinical investigation. We believe this approach will offer the best opportunity to provide the scientific rationale for the development of improved therapies to treat certain disorders of reproduction and serve as the basis for the development of better options for hormonal contraception in men. We are committed to scientific excellence and communication across disciplines, ranging from molecular biology to physiology and medicine. Our proposal incorporates the talents of outstanding investigators, whose experience and knowledge represent a rich and broad perspective on reproductive biology and its relevance to human health. We have deliberately structured the Center to bring together the best and most accomplished reproductive biologists and physician-scientists at the University of Washington in a scientific collaboration. We look forward to our continued participation in the NIH Specialized Cooperative Centers Program in Reproductive Research (SCCPRR). We share its goal of fostering communication, innovation and research excellence, with the ultimate goal of improving human reproductive health through accelerated transfer of discoveries made at the bench into clinical practice. We are committed to the collaborative spirit of the SCCPRR and have established collaborations with investigators at SCCPRR Programs at several other institutions. We look forward to contributing to the outstanding clinical and basic research in this important national program.