UMDNJ/Rutgers University CounterACT Research Center of Excellence

硫磺芥末是一种强有力的化学战发泡剂，被认为是一种高度优先的化学威胁。 虽然对它的研究已有80多年的历史，但其作为发泡剂的作用机制 仍然不为人知；此外，到目前为止，还没有有效的医学对策来应对战争。 发泡剂。拟议的UMDNJ/罗格斯大学对抗卓越研究中心将 具体重点是开发治疗硫芥末中毒的药物。在合作研究中与 当地一家制药公司和巴特尔纪念研究所，我们已经确定了两个候选类别 可以预防或逆转硫芥子中毒的药物。每个班级至少有一名成员 药物此前已被FDA批准用于其他适应症。在这个学术/工业领域 伙伴关系，计划从我们已经确定的基团中优化先导化合物，以确定 活性药效团，并最终合成结构异构体。我们还将评估 在硫芥毒性模型系统中的这些潜在的对策。此外，研究和 提出了旨在确定硫的具体作用机制的开发项目 芥末和潜在的新靶点在三个主要发泡靶点的治疗干预：眼睛， 皮肤和肺。这些项目的调查人员将与一家药理学和药物公司密切合作 开发核心和具有相当药物专业知识的药物化学和药物制剂学核心 为硫磺芥菜的发展提供有益的启示和对策。这个 研究开发项目的研究实验室，药剂学 集团与药理学和药物开发核心公司在 罗格斯大学布希校区。他们都是环境和职业健康协会的成员。 科学研究所(EOHSI)，由UMDNJ-Robert Wood Johnson医学院联合赞助的设施 以及罗格斯大学的药学院。EOHSI已被指定为NIEHS中心 太棒了。药物化学小组位于利哈伊大学，距离 罗格斯大学。该中心的P.I.(J.Laskin)和药物化学核心的P.I.(N. Heindel)由NIEHS联合资助药物开发赠款已超过15年。一次培训和 教育计划将针对罗格斯大学学院的医疗保健提供者 药剂学，UMDNJ-公共卫生学院，UMDNJ-Robert Wood Johnson医学院和健康 利哈伊大学的理科课程。

Sulfur mustard, a potent chemical warfare vesicant, is considered to be a high priority chemical threat. Although it has been studied for more than 80 years, the mechanisms mediating its actions as a vesicant remain unknown; moreover, to date, there are no effective medical countermeasures for exposure to warfare vesicants. The proposed UMDNJ/Rutgers University CounterACT Research Center of Excellence will specifically focus on the development of drugs to treat sulfur mustard poisoning. In collaborative studies with a local pharmaceutical company and Battelle Memorial Institute, we have identified two candidate classes of Pharmaceuticals that can prevent or reverse sulfur mustard toxicity. At least one member of each class of drugs has previously been approved by the FDA for other indications. In this academic/industrial partnership, plans are to optimize the lead compounds from the groups we have identified, to determine the active pharmacophores, and ultimately to synthesize structural isomers. We will also evaluate the efficacy of these potential countermeasures in model systems of sulfur mustard toxicity. In addition, Research and Development Projects are proposed that are designed to identify specific mechanisms of action of sulfur mustard and potential new targets for therapeutic intervention in three major vesicant targets: the eye, the skin and the lung. Investigators on these projects will work closely with a Pharmacology and Drug Development Core and a Medicinal Chemistry and Pharmaceutics Core with considerable expertise in drug development, providing insights to facilitate the development of sulfur mustard countermeasures. The research laboratories of the PI, co-Pi, Pi's of the Research and Development Projects, the Pharmaceutics group and Pharmacology and Drug Development Core are located in close proximity to one another on the Busch campus of Rutgers University. They are all members of the Environmental and Occupational Health Sciences Institute (EOHSI), a facility jointly sponsored by UMDNJ-Robert Wood Johnson Medical School and the School of Pharmacy at Rutgers University. EOHSI has been designated as an NIEHS Center of Excellence. The Medicinal Chemistry group is located at Lehigh University, approximately 25 miles from Rutgers University. The P.I. of this Center (J. Laskin) and the P.I. of the Medicinal Chemistry Core (N. Heindel) have been jointly funded by NIEHS on drug development grants for over 15 years. A Training and Education Program is proposed that will be directed at health care providers at Rutgers University School of Pharmacy, UMDNJ-School of Public Health, UMDNJ-Robert Wood Johnson Medical School and the Health Sciences Program at Lehigh University.