Training in the Molecular Basis of Skin/Mucosa Parthobiology

描述（由申请人提供）：俄勒冈健康与科学大学（OHSU）皮肤学系建议继续其“皮肤病理生物学分子基础培训”计划，目标是培养实验皮肤病学和相关上皮疾病，特别是癌症和炎症性疾病的高素质博士前和博士后研究人员。具体来说，我们的目标是：1；使学员进一步了解粘膜和皮肤疾病背后的分子途径，发展和使用推进该领域所需的专门方法，并提供见解并最终应用于临床问题；第二，促进我们的导师/学员实验室之间的互动，丰富皮肤病学领域，扩大其范围和影响，以理解和治疗疾病。该计划提供了一个核心导师，包括来自皮肤科研究部门和5个基础科学部门的国际公认的教师研究人员，他们通过该计划相互作用和合作，形成对上皮癌变和炎症性疾病的关注。培训计划旨在通过以下方式实现这些目标：1)让学员和导师在上皮癌变和表面上皮炎症性疾病的多个领域进行讨论，互动/协作，分享想法和方法(通过每月轮换学员报告所有学员和导师参加的数据，共同指导，2)通过与临床皮肤科医生和肿瘤学家的密切互动（通过我们每月的翻译主题论坛和期刊俱乐部以及住院医生和科学家的联合报告来促进），让学员了解基础科学到临床治疗的转化。该项目涵盖皮肤和粘膜癌变、稳态、致癌和肿瘤抑制机制（Trim32、Wnt、TGF¿1/SMAD、c-Myc、Ras和B-Raf、胰岛素样生长因子、Cox2、Piasy、p73、抑制性SMAD），以及癌症和炎症疾病中的细胞因子，并促进专业研究资源的共享，用于培训项目(皮肤、结肠癌、头颈癌和炎症疾病的上皮靶向基因开关模型、非侵入性光学成像；上皮细胞和免疫群体的特化细胞分离；我们的分子图谱资源包含新鲜冷冻保存的人类肿瘤标本和正常粘膜和皮肤对照)。每年任命两名博士预科生和三名博士后医学博士，博士或医学博士/博士候选人，选择他们的才能，他们带来的特殊经验，以及他们进行具有强大临床转化成分的皮肤/粘膜研究的愿望，以及对癌症和炎症领域的调查皮肤病学的潜在影响。

DESCRIPTION (provided by applicant): The Oregon Health & Science University (OHSU) Department of Dermatology proposes continuation of its "Training in the Molecular Basis of Skin Pathobiology" program with objectives to train highly qualified predoctoral and postdoctoral researchers for academic careers in experimental dermatology and related epithelial disorders, in particular cancer and inflammatory disease. Specifically we aim: 1. to engage trainees in furthering an understanding of the molecular pathways that underlie mucosal and skin disease, in evolving and using specialized approaches needed to advance the field, and in providing insight and ultimately application to clinical problems; and 2, to foster interactions among our mentor/trainee laboratories that enrich the dermatology field and increase its scope and impact on understanding and treating disease. The proposed program offers a core of mentors including internationally recognized faculty researchers from the Dermatology research division and 5 basic science departments who through this program interact and collaborate to form a focus on epithelial carcinogenesis and inflammatory disease. The training program is designed to achieve these aims by 1) engaging trainees and mentors in discussion, interaction/collaboration and sharing ideas and approaches in multiple areas of epithelial carcinogenesis and inflammatory disease of surface epithelia (facilitated through monthly rotation of trainee presentations of data attended by all trainees and mentors, co-mentoring, and sharing specialized resources) and 2) exposing trainees to translation of basic science to clinical treatment through close interaction with clinical dermatologists and oncologists (facilitated through our monthly translational topics forum and journal clubs with joint presentations of residents and scientists). This program spans skin and mucosal carcinogenesis, homeostatic, oncogenic and tumor suppressor mechanisms (Trim32, Wnt, TGF¿1/SMAD, c-Myc, Ras and B-Raf, insulin-like growth factors, Cox2, Piasy, p73, inhibitory SMADs), and cytokines in cancer and inflammatory disorders, and fosters sharing of specialized research resources for use in trainee projects (epithelial-targeted gene-switch models of skin, colon, and head and neck cancer and inflammatory disease; non-invasive optical imaging; specialized cell isolation of epithelial and immune populations; and our Molecular Profiling Resource containing freshly cryopreserved human tumor specimens and normal mucosa and skin controls). Two predoctoral and three postdoctoral MD, PhD or MD/PhD candidates are appointed each year, selected for their aptitude, the special experience they bring to the field and their desire to carry out skin/mucosa research with a strong clinical translational component and potential for impact on investigative dermatology in the areas of cancer and inflammation. RELEVANCE: This program studies cancer and inflammatory diseases of surface organs of the body (skin, oral and intestinal mucosa), to understand how they are caused at the tissue, cellular, molecular and biochemical levels, and to discover new treatments. Skin is a good model because we can see cancer and inflammatory diseases develop from their earliest stages and easily see responses to new treatments; however our group is developing non-invasive imaging that allows us to see oral and intestinal disease as well and to connect the pathology with changes in adult stem cells, cancer gene expression and inflammation-promoting molecules at these organ sites. Cancers of these and related epithelia make up the majority of human cancers, the most deadly of these affecting over 680,000 people a year in the US, with nearly 300,000 deaths, while psoriasis alone (a skin inflammatory disease) affects ~ 7.5 million people in the US annually,