Comprehensive Training Grant in Bone Biology and Disease

描述(由申请者提供)：DAB骨生物学和疾病综合研究培训计划的竞争性更新提供了培养具有创新骨相关研究能力的独立研究科学家所需的严格的跨学科教育。自四年前成立以来，一名博士后实习生和包括一名学术临床医生在内的五名博士后完成了该项目；其中四人在从事骨生物学研究，三人在学术界，一人在工业。该计划利用UAB-代谢性骨病中心(主任：J.McDonald，MD)的资源和研究基础，该中心是全国五个由P30资助的骨骼项目之一。培训计划的33名导师是根据他们在临床和基础研究、动态研究计划和模范培训记录方面的互补研究专长而选出的。现有的基础研究项目包括使用新模型结合尖端技术分析骨丢失的基本生物学；骨质疏松症、其他代谢性骨疾病、糖皮质激素引起的骨丢失、牙病、转移性骨病和骨肉瘤；生物材料/植入研究；以及基因治疗转移技术。临床研究项目(流行病学、预防、结果和有效性研究；诊断学的发展；以及临床试验)利用临床教师对长期、多机构研究的参与。培训计划由麦克唐纳博士(主席：病理学)在两名副主任和一个咨询委员会的协助下管理。基础研究的学员被要求参加全部或部分综合生物医学科学(IBS)计划，该计划提供从方法驱动的分子生物学和遗传学分析过渡到与临床相关的、基于问题的研究所必需的基于器官和细胞的基础科学培训。博士前实习生在UAB攻读IBS、生物医学工程、细胞和分子生物学或医学/博士研究生课程。在过去的四年里，通过战略招聘，扩大了与骨骼相关的课程，并加强了教师队伍。正在进行的机构对骨骼研究的承诺导致了最先进的设施的重大扩展，并在UAB开发了新的跨学科项目，进一步加强了研究基础和课程。需要为三名博士后和三名博士后实习生提供经费。相关性：该计划培养的科学家将尖端的分子和细胞方法应用于发现、开发和测试治疗方法，以预防和治疗与骨质疏松症、类风湿性关节炎和其他疾病相关的骨丢失，促进骨创伤愈合，以及开发具有更好的生物兼容性和寿命的整形外科和牙科植入物。

DESCRIPTION (provided by applicant): This competitive renewal of the comprehensive Research Training Program in Bone Biology and Disease at DAB provides the rigorous interdisciplinary education required for the development of independent research scientists capable of innovative bone-related research. Since its establishment four years ago, one predoctoral trainee, who is now a postdoctoral fellow in implant biology and materials research, and five post-doctoral students, including an academic clinician, have completed the program; four of whom are pursuing bone biology research, three in academics and one in industry. The Program leverages the resources and research base of in the UAB-Center for Metabolic Bone Disease (Director: J. McDonald, MD), one of five P30-funded bone programs in the nation. The 33 preceptors of the Training Program have been selected based on their complementary research expertise in clinical and basic research, dynamic research programs, and exemplary training records. Available basic research projects include the use of novel models combined with cutting-edge technologies in the analysis of the basic biology of bone loss; osteoporosis, other metabolic bone diseases, and glucocorticoid-induced bone loss, dental disease, metastatic bone disease and osteosarcoma; biomaterials/implant research; and gene therapy transfer technology. The clinical research projects (epidemiology, prevention, outcomes, and effectiveness studies; development of diagnostics; and clinical trials) exploit the participation of clinical faculty in long-term, multi-institutional studies. The Training Program is administered by Dr. McDonald (Chair: Pathology) with the assistance of two Associate Directors, and an Advisory Committee. Trainees in basic research are required to take all or part of the Integrative Biomedical Sciences (IBS) Program, which provides organ- and cell-based basic science training necessary for transition from methods-driven molecular biology and genetics analyses into clinically-relevant, problem-based studies. Predoctoral trainees are enrolled in the IBS, Biomedical Engineering, Cellular and Molecular Biology, or MD/PhD Graduate Programs at UAB. In the past four years, the bone-related curriculum has been expanded and the faculty strengthened through strategic recruitment. The ongoing institutional commitment to bone research has resulted in a major expansion of state-of-the-art facilities and the development of new interdisciplinary programs at UAB that further strengthen the research base and curriculum. Funding is requested for three predoctoral and three postdoctoral trainees. Relevance: This program produces scientists who apply cutting edge molecular and cellular approaches to the discovery, development, and testing of therapeutics for the prevention and treatment of bone loss associated with osteoporosis, rheumatoid arthritis, and other diseases, and the promotion of bone wound healing, as well as the development of orthopedic and dental implants with greater biocompatibility and longevity.