Interdisciplinary Training Program Muscle Biology

描述(由申请者提供)：该项目为博士后和博士后学生提供肌肉生物学的跨学科培训。该计划强调骨骼肌、心肌和平滑肌的功能、结构和分子特性。我们的16名教职员工来自马里兰大学巴尔的摩分校医学院的4个基础科学系和2个跨部门学位授予项目，以及马里兰大学生物技术研究所的2个系。附属教员也来自我们的姊妹大学马里兰大学巴尔的摩县分校工程学院的1个系。学员来自所有参与的部门和项目。培训范围包括肌肉发育的分子生物学决定因素、肌肉蛋白质结构和功能的分子方面、肌肉细胞骨架和基质的细胞生物学方面、对单个肌肉细胞功能的生物物理和生理分析以及整个肌肉和肌肉器官的生物力学特性，以反映我们不同的教职背景。我们的教师在肌肉功能和肌肉细胞骨架和基质的钙控制领域得到了国内和国际的认可。我们的学生将接受这些和各种相关领域的培训，重点是使用几种免费的技术来处理每个调查问题。博士前培训的主要教学方面将是两门为期一学期的肌肉跨学科课程，这两门课程已经由项目教员定期提供，并得到了过去的学生群体的好评。我建议开始续期，第一年和第二年有4名博士前实习生，增加！在第三年、第四年和第五年到5名博士后，从6名博士后实习生开始，并在整个授权期内保持这一水平。进入博士前培训的学员将继续拥有扎实的生物、化学和/或物理背景，优异的GRE成绩和强有力的推荐信。博士后实习生将完成扎实的博士论文，并有强有力的推荐信。这个项目的学员将准备好运用广泛的方法来回答肌肉生物学中的基本问题，以及肌肉疾病及其可能的治疗或最终治愈的基础。因此，该计划服务于全国对肌肉功能和疾病的称职多学科调查人员的需求。

DESCRIPTION (provided by applicant): This program provides interdisciplinary training in muscle biology for pre- and postdoctoral students. The program emphasizes the functional, structural and molecular properties of skeletal, cardiac and smooth muscle. Our 16 faculty members come from 4 basic science departments and two interdepartmental degree granting programs at the School of Medicine, University of Maryland at Baltimore, and 2 departments in the University of Maryland Biotechnology Institute. Affiliate faculty also come from 1 department in the College of Engineering at our sister campus, University of Maryland Baltimore County. Trainees are drawn from all of the participating departments and programs. Reflecting our diversity of faculty backgrounds, the training offered will range from the molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle cytoskeleton and matrix, biophysical and physiological analysis of individual muscle cell function and biomechanical properties of whole muscles and muscular organs. Our faculty is nationally and internationally recognized in the areas of calcium control of muscle function and muscle cytoskeleton and matrix. Our students will receive training in these and in a variety of related areas, with emphasis on the use of several complimentary techniques to approach each question under investigation. The: major didactic aspect of the pre-doctoral training will be two one-semester interdisciplinary courses on muscle that are already regularly offered by the program faculty and which have been well received by past student groups. i We propose to begin the renewal period with 4 pre-doctoral trainees in the first and second years, to increase! to 5 pre-docs in the third, fourth and fifth year and to begin with 6 postdoctoral trainees and maintain that level throughout the granting period. Entering pre-doctoral trainees will continue to have a solid background in biology, chemistry and/or physics, excellent GRE scores and strong letters of recommendation. Incoming]' postdoctoral trainees will have completed a solid PhD thesis and have strong letters of recommendation.! Trainees from this program will be prepared to bring a wide range of approaches to bear on answering basic questions in muscle biology and on the bases for muscle diseases and their possible treatment or eventual cure. The program therefore serves a national need for competent multi-disciplinary investigators of muscle function and disease.