Creating A Biomarker Registry for Secondary Data Collections

描述(由申请人提供)：本申请请求R21探索性资金，以开发方法和工具，导致在公开可获得的二级数据收集中发现的生物标记物和健康变量的全面登记。拟议的试点将首先从国家老龄问题计算机化数据档案馆和大学间社会和政治学联合会保存的收藏品中提取数据。我们将利用这个基础建立协议，以审查和确定其他收集中衡量生物和医学指标的变量，这些指标通常被称为生物标记物，使我们能够创建此类指标的全面登记，供公众使用。作为许多调查的一部分，越来越多的被定义为生物标记物的变量被例行收集；这项申请首次提出了一种有效的办法，将这一不断增长的信息编入登记系统，并促进将这些数据用于二次研究。第一年拟议的评估和鉴定进程将建立一个框架，在第二年将建立一个广泛的系统，纳入来自NACDA内部和我们已建立的档案之外的数据收集的生物标记物信息。项目说明： 这项工作涉及组织研究数据，以提供获取和关于健康的生物和医学指标的信息。该项目将帮助研究人员开展原创性研究，研究医学测试、肥胖和其他健康因素对个人生活的影响。

DESCRIPTION (provided by applicant): This application requests R21 exploratory funds to develop methodology and tools leading to a comprehensive registry of biomarker and health variables found in publicly available secondary data collections. The proposed pilot will begin with data drawn from collections maintained by the National Archive of Computerized Data on Aging (NACDA) and the Inter-University Consortium of Social and Political Science (ICPSR). We will use this base to establish protocols to review and identify variables in other collections that measure biological and medical indicators commonly referred to as biomarkers allowing us to create a comprehensive registry of such indicators for public use. Increasingly variables defined as biomarkers are routinely collected as part of many surveys; this application is the first to propose an effective approach for organizing this growing universe of information into a registry system and to promote the use of these data for secondary research. The evaluation and identification process proposed for year one will establish a framework that, in the second year, will establish a broad system to incorporate biomarker information from data collections maintained both within NACDA and outside our established archives. Project Narrative: This work addresses the organization of research data to provide access to and information on biological and medical indicators of health. The project will help researchers develop original research that studies the impacts of medical tests, obesity and other health factors on the lives of individuals.