Identifying the neural signature of persistent pain

慢性疼痛影响着超过20%的澳大利亚人。尽管它的患病率很高，但它对目前的治疗方案相对有抵抗力，我们提供令人满意的疼痛缓解能力不足的部分原因是由于我们对这种情况的病理生理学的理解有限。这一建议将对与慢性疼痛相关的中枢神经可塑性变化以及这些变化在这些疾病的维持中所起的作用产生新的理解。

Chronic pain affects over 20% of Australians. Despite its high prevalence, it is relativly resistant to current treatment regimes and part of the reason behind our inadequate ability to provide satisfactory pain relief is due to our limited understanding of the pathophysiology that underlies this condition. This proposal will develop a novel understanding of the central neuroplastic changes associated with chronic pain and the role that these changes play in the maintenance of these conditions.