Molecular Mechanisms of Immune Tolerance

描述（由申请人提供）：我们请求支持一个博士后培训计划，重点是免疫耐受和自身免疫的分子机制。该应用程序是在免疫学的综合部门的发展，其教师是强烈专注于B和T细胞的发展，抗原识别，剧目的发展，沉默编辑，删除和无能，并了解自身免疫的高跟鞋。免疫学综合系由来自三个机构的56名教师（小学和中学）组成：国家犹太医学和研究中心（NJMRC），芭芭拉戴维斯儿童糖尿病中心（BDC）和科罗拉多大学丹佛分校和健康科学中心（UCDHSC）。自1999年成立以来，21名培训教师中有近一半已被招募到该部门，所有培训教师都得到NIH R0I赠款的支持，他们是首席研究员。我们请求为4名研究员提供津贴支持，他们将在自己选择的实验室接受培训。研究员将参加定期安排的期刊俱乐部、研究进展研讨会、正式研讨会和课程，例如，培训监督委员会将监督这些课程的进展情况。受训人员的任期为一年，只有在目标为本课程评估为有显著进步的情况下，才可获重新聘用。我们的目标是为研究员提供免疫耐受和自身免疫小鼠模型的全面知识，以及对临床自身免疫的充分理解，使他们能够发展富有成效的临床合作关系，以翻译研究。项目主任是约翰·坎比尔博士，艾达和塞西尔绿色教授和免疫学综合系主任。Cambier博士是B细胞信号传导、活化和无反应性方面的专家，并培训了60多名研究生和博士后研究员。该培训计划拥有一流的研究设施。教师在培训和研究方面都是互动的。虽然丹佛免疫学社区已经培养了30多年的博士前和博士后研究员，但免疫学综合系的成立和新教师的聘用提供了强大的团结影响力，并为我们的教育和研究活动注入了新的活力和活力。这项培训计划是这种活力的中心焦点。

DESCRIPTION (provided by applicant): We request support for a postdoctoral training program focused on molecular mechanisms of immunologic tolerance and autoimmunity. This application comes on the heels of development of an Integrated Department of Immunology whose faculty is strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and understanding autoimmunity. The Integrated Department of Immunology is comprised of 56 faculty (primary and secondary) from three institutions: the National Jewish Medical and Research Center (NJMRC), The Barbara Davis Center for Childhood Diabetes (BDC) and The University of Colorado at Denver and Health Sciences Center (UCDHSC). Nearly half of the 21 training faculty have been recruited to the Department since its inception in 1999, and all training faculty are supported by NIH R0I grants on which they are Principal Investigator. We request stipend support for 4 fellows who will train in laboratories of their choosing. The fellows will participate in regularly scheduled journal clubs, research in progress seminars, formal seminars and courses, e.g., on ethics and survival skills in science, and their progress will be monitored by a training oversight committee (TOC). Trainees will be appointed for one year and reappointed only if they are judged by the TOC to be making significant progress. Our goal is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. The Program Director is Dr. John Cambier, Ida and Cecil Green Professor and Chairman of the Integrated Department of Immunology. Dr. Cambier is an expert in B cell signaling, activation and anergy, and has trained in excess of 60 graduate students and postdoctoral fellows. The training program has available superb research facilities. and the faculty are interactive in both training and research. Although the Denver immunology community has been training pre- and postdoctoral fellows for over 30 years, the formation of the Integrated Department of Immunology and hiring of new faculty has provided a strongly uniting influence, and injected new excitement and vitality into our educational and research activities. This training program is a central focus of that vitality.