Interdisciplinary Training in Transplantation Biology

描述（由申请人提供）：移植是一个快速发展的、具有挑战性的临床医学领域，在治疗许多人类疾病方面具有巨大的潜力。这一领域为基础科学家和临床医生之间的有效互动提供了令人兴奋的机会。匹兹堡大学的Starzl移植研究所和医学院的院系提供了一个独特的学术环境，有利于年轻的基础科学家和医生在移植生物学方面的全面，广泛的培训，重点是免疫学和细胞和分子病理学。我们提出了一个跨学科的研究计划，以培养研究生和博士后研究人员，以帮助确保训练有素的研究人员可以在学术界、工业界和政府附属的研究中担任领导角色。参与研究的教师具有不同但互补的研究兴趣，有成功的富有成效的合作记录，并致力于培训年轻的研究人员，他们将传授移植生物学方面的技能，包括免疫遗传学、缺血再灌注损伤、抗原提呈细胞和T细胞生物学、耐受性诱导、肝脏免疫学、移植传染病生物学、慢性排斥反应、复合组织移植、同种异体和异种识别、异种移植和新型治疗性免疫抑制剂/方案的发展。该培训计划的主要目标是培养杰出的，潜在的独立研究者，能够解决移植生物学的基本问题，并具备适当的生存和职业发展技能。博士前培训生将从匹兹堡大学医学院跨学科生物医学研究生培训计划的研究生中挑选，这些研究生对移植生物学的博士研究感兴趣。第一年有2名博士生预科生，随后几年有4名博士生，在第一年、第二年、第三年或第四年的学生之间分配。具有博士、博士或博士/博士学位的博士后培养生将根据其突出的潜力选择，并给予2年的资助。第一年资助2名博士后，以后每年资助4名博士后。

DESCRIPTION (provided by applicant): Transplantation is a rapidly-expanding, challenging area of clinical medicine with great potential for the cure of many human diseases. This field provides exciting opportunities for the productive interaction between basic scientists and clinicians. The University of Pittsburgh's Starzl Transplantation Institute and Departments in the School of Medicine provide a unique academic environment conducive to the comprehensive, broad-based training of young basic scientists and physicians in transplantation biology with an emphasis on immunology and cell and molecular pathology. We propose an interdisciplinary research program to train graduate and postdoctoral researchers to help ensure that highly-trained investigators are available to assume leadership roles in academia, industry and government-affiliated research. Participating faculty with diverse but complementary research interests, a successful record of productive collaboration and a commitment to training young investigators, will impart skills in transplantation biology, including expertise in immunogenetics, aspects of ischemia-reperfusion injury, antigen-presenting cell and T cell biology, tolerance induction, liver immunology, biology of transplant infectious disease, chronic rejection, composite tissue transplantation, evolution of allo- and xenorecognition, xenotransplantation and novel therapeutic immunosuppressive agents/regimens. The principal goal of this training program is to produce outstanding, potentially independent investigators, able to address fundamental questions in transplantation biology and equipped with appropriate survival and career development skills. Predoctoral trainees will be selected from graduate students enrolled in the Interdisciplinary Biomedical Graduate Training Program at the University of Pittsburgh School of Medicine, who express interest in pursing PhD research in transplantation biology. Support is requested for 2 predoctoral trainees in the initial year and for 4 trainees in subsequent years, distributed between students in their 1st, 2nd, 3rd or 4th year of research. Postdoctoral trainees with MD, PhD, or MD/PhD degrees will be selected based on their outstanding potential and will be supported for 2 years. Support is requested for 2 postdoctoral trainees in the initial year, and for 4 trainees in subsequent years.