Harvard Longwood Medical Area Training Grant in Transplantation

描述（由申请人提供）：移植是一个令人兴奋和迅速发展的领域，在治疗人类疾病方面具有巨大的潜力。该机构培训计划的目的是为年轻科学家和内科科学家提供机会，进行与移植免疫学基础研究相关的各种主题的培训，重点是免疫机制。为此，我们制定了哈佛朗伍德医学区广泛的联合培训计划，在该计划中，具有不同但互补的研究兴趣、合作记录和对培训年轻研究人员的承诺的高度协作和富有成效的教师小组将为致力于移植生物学事业的个人提供指导。该学院将为博士生提供接受移植免疫学相关主题培训的机会，包括耐受性、T细胞活化、MHC结构和功能、基因治疗、淋巴细胞运输、骨髓移植、血管生物学、干细胞生物学、淋巴细胞发育调节、传染病、自身免疫、胰岛移植、生物信息学和异种移植。主要目标是培养能够解决移植领域基本问题的杰出独立研究者。教职员工的经验和奉献精神，以及由哈佛朗伍德医学区的主要教学医院和哈佛医学院组成的研究环境，为实现这一目标提供了独特的环境。博士预科生将根据对移植免疫学领域的论文研究的兴趣从哈佛大学医学部免疫学项目中选择。在随后的所有年份中，要求为1名第一年和第二年的博士预科生提供支持，并在论文研究的第一、第二、第三或第四年的学生之间分配。博士预科学生的培训大约需要4年。目前持有医学博士、博士学位或医学博士、博士学位的博士后，将根据其在科研、教学方面的突出潜力和对独立研究的承诺来选择。在培训计划的第1年和第2至第5年，要求支持2名博士后学员和4名博士后学员。培训时间为3年。受训者将从参与培训的教员中选择一名主要研究顾问，该顾问将监督受训者的日常研究工作。所有受训者都将参与一个互动的环境，包括正式的课程作业、部门和部门间的系列研讨会、期刊俱乐部和实验室会议。这种互动环境将确保所有受训者接触到各种各样的学科，并将帮助他们为在移植免疫学这一与人类健康直接相关的领域独立从事职业做好准备。

DESCRIPTION (provided by applicant): Transplantation is an exciting and rapidly expanding field with great potential for curing human disease. The purpose of this institutional training program is to provide opportunities for young scientists and physician scientists for training in a wide variety of topics related to basic research transplantation immunology with an emphasis on immunological mechanisms. To this end, we have developed a Harvard Longwood Medical Area wide combined training program in which a highly collaborative and productive group of faculty with diverse but complementary research interests, a record of collaboration, and a commitment to training young investigators will serve to mentor individuals committed to a career in transplantation biology. The faculty will provide pre- and postdoctoral trainees with the opportunity to receive training in topics related to transplantation immunology including tolerance, T cell activation, MHC structure and function, gene therapy, lymphocyte trafficking, bone marrow transplantation, vascular biology, stem cell biology, regulation of lymphocyte development, infectious disease, autoimmunity, islet transplantation, bioinformatics, and xenotransplantation. The major goal is to produce outstanding independent investigators capable of addressing fundamental questions in the field of transplantation. The experience and dedication of the faculty, as well as the research environment comprised of the major teaching hospital within the Harvard Longwood Medical Area and Harvard Medical School provide a unique environment in which this goal can be accomplished. Pre-doctoral trainees will be selected from the Immunology Program at Harvard University's Division of Medical Sciences based on their interest in pursuing dissertation research in the field of transplantation immunology. Support is requested for 1 pre-doctoral trainee in year 1 and 2 in all subsequent years, distributed between students in their 1st, 2nd 3rd, or 4th year of thesis research. Training for pre-doctoral students will take approximately 4 years. Postdoctoral trainees currently holding a degree of MD, PhD, or MD, PhD will be selected based on having outstanding potential to pursue a career in research and teaching and a commitment to independent investigation. Support is requested for 2 postdoctoral trainees in year 1 and 4 in years 2 through 5 of the training proposal. Training will require 3 years. Trainees will choose a primary research advisor from the participating training faculty that will oversee daily research endeavors of the trainee. All trainees will participate in an interactive environment comprised of formal course work, departmental and interdepartmental seminar series, journal club, and laboratory meetings. This interactive environment will insure that all trainees are exposed to a wide variety of disciplines and will help prepare them for an independent career in transplantation immunology, a field with direct relevance to human health.