Predoctoral Training in Exercise Physiology and Aging

描述（由申请人提供）：马里兰州学院公园运动生物学系和衰老计划的大学有生产训练有素的博士谁完成博士后培训，并成为富有成效的教师的历史。我们已经支持了18名学员在这个计划的前9年，其中12人完成了博士学位，5人仍在培训中，1人在不同的学科（神经科学）攻读MD/博士学位。12名毕业生中有11人（92%）获得了NIH博士后研究奖学金。这12名毕业生中有7名现在担任终身教职，1名在工业界，1名兼职教师，3名仍在博士后职位上。此外，我们已经毕业了3名非洲裔美国妇女，她们在UT西南，维克森林和坦普尔获得了NIH博士后研究奖学金。该计划为学员提供必要的技能，使他们能够完成高质量的论文研究项目，解决：1）身体成分，代谢，CV和肌肉骨骼功能的年龄相关变化，以及CV疾病的危险因素; 2）运动训练引起的这些相同参数的变化; 3）这些参数的基线测量的遗传结构，它们随衰老的变化，以及它们随运动训练干预的变化;和4）使用细胞和分子生物学方法在动物和细胞培养模型中负责这些应答的机制。这一更新培训计划的一个实质性增强是这种翻译的组成部分，学员可以将他们的研究从人类生理学研究扩展到动物模型和细胞培养的研究，以描绘潜在的细胞和分子机制。学员的研究可以在马里兰州大学医学院老年学分部、内分泌学、糖尿病和营养学分部、生理学系以及护理和儿童学院国家医学中心遗传医学研究中心的密切合作实验室与初级、中级和副导师进行。学员完成课程的基础生物学老化;在运动，CV，肌肉骨骼，代谢，细胞和分子生物学和生理学的具体知识;遗传学;和生物统计学和研究设计。我们建议继续这项计划，资助6名博士前学员每人4年，以高质量的课程和论文研究项目完成他们的博士学位，这将使他们为NIH博士后研究奖学金和最终的学术教师职位做好准备，该研究计划侧重于运动生物学和衰老。 相关性：该计划将支持6名学员/年谁将完成他们的博士学位与高质量的研究项目。长期目标是培养学员追求高水平的国家卫生研究院博士后研究奖学金，并最终，学术教师职位，专注于研究和教学，在预防这些主要的年龄相关的问题，如肌肉减少症，肥胖，糖尿病，高血压和心血管疾病。

DESCRIPTION (provided by applicant): The University of Maryland College Park Department of Kinesiology exercise biology and aging program has a history of producing well-trained PhDs who complete postdoctoral training and become productive faculty members. We have supported 18 trainees over the first 9 yrs of this program with 12 completing their PhD degrees, 5 still in training, and 1 pursuing an MD/PhD degree in a different discipline (neuroscience). Eleven of the 12 who graduated (92%) have gone on to NIH postdoctoral research fellowships. Seven of these 12 graduates are now in tenure-track academic positions, 1 is in industry, 1 is part-time faculty, and 3 are still in postdoctoral positions. Furthermore, we have graduated 3 African-American women who have gone on to NIH postdoctoral research fellowships at UT-Southwestern, Wake Forest, and Temple. This program provides trainees with the skills necessary for them to complete high-quality dissertation research projects addressing: 1) age-related changes in body composition, metabolic, CV, and musculoskeletal function, and CV disease risk factors; 2) exercise training-induced changes in these same parameters; 3) the genetic architecture underlying the baseline measures of these parameters, their changes with aging, and their changes with exercise training interventions; and 4) the mechanisms responsible for these responses in animal and cell culture models using cell and molecular biology methodologies. A substantial enhancement of this renewal Training Program is this translational component, whereby trainees can extend their studies from human physiological studies to investigations in animal models and cell culture to delineate the underlying cell and molecular mechanisms. Trainees' research can be conducted with Primary, Secondary, and Associate Mentors at closely collaborating laboratories at the University of Maryland School of Medicine Division of Gerontology, Division of Endocrinology, Diabetes, and Nutrition, Department of Physiology, and School of Nursing and Childrens National Medical Center Research Center for Genetic Medicine. Trainees complete coursework in the basic biology of aging; specific knowledge in exercise, CV, musculoskeletal, metabolic, cell, and molecular biology and physiology; genetics; and biostatistics and research design. We propose to continue this program to fund each of 6 predoctoral trainees for 4 yrs to complete their PhD degrees with high-quality coursework and a dissertation research project that will prepare them for an NIH postdoctoral research fellowship and an eventual academic faculty position with a research program focusing on exercise biology and aging. RELEVANCE: This program will support 6 trainees/yr who will complete their PhD degrees with high quality research projects. The long-term goal is to prepare trainees to pursue high-level NIH postdoctoral research fellowships and, eventually, academic faculty positions that focus on research and teaching in the prevention of such major age-associated issues as sarcopenia, obesity, diabetes, hypertension, and CV disease.