Real-Time Tomosynthesis Imaging for Vascular Dynamics

描述（由申请人提供）：恶性肿瘤的生理特征，如血流和血管渗透性与治疗效果密切相关。断层血管动态信息在监测肿瘤生长和血管募集以及评估新型化疗药物的治疗反应方面具有巨大的实用性。我们建议开发一个实时断层合成（TS）系统，通过将新的固定X射线源阵列技术与现有的平板探测器相结合来成像血管动力学。该系统将适用于中等大小的对象，如人类乳房或小动物，特别是小鼠和大鼠的血管研究，因为它们被广泛用于人类疾病模型，包括癌症。动态成像系统将提供时间分辨的断层图像。在我们设计，制造和鉴定系统后，我们将使用Phantom来评估它，以获取实时断层图像数据集。这些数据集将提供重要的信息，以指导进一步的工程发展的固定X射线源技术和实时TS系统。这一R21建议的具体目标是：目标1。建立一个实时多源断层成像系统血管分析（第一年）目标2。演示固定源操作和量化系统的时间和空间性能使用幻影和国家的最先进的图像评估技术。(Year 2）本提案中提出的用于演示的固定X射线源可能会对医学成像技术的其他领域产生重大影响。提高成像速度的潜力和实施新的采集几何形状赋予这样的来源可能会导致开发紧凑，负担得起的CT和数字TS系统，用于医院，诊所，农村地区和实验室，从而有利于医疗保健和研究领域。公共卫生相关性：我们建议通过开发一种X射线成像系统来显着改进医学成像技术，该系统将允许癌症研究人员拍摄三维X射线运动图像。提高成像速度、降低系统成本以及实现由这种设备赋予的新颖采集几何形状的潜力可以导致开发紧凑的、负担得起的CT和数字断层合成系统，用于医院、诊所、农村地区和实验室，从而使医疗护理和研究领域受益。

DESCRIPTION (provided by applicant): Physiological characteristics of malignant tumors such as blood flow and vascular permeability are strongly coupled to therapeutic effects. Tomographic vascular dynamic information is of enormous utility in monitoring tumor growth and vessel recruitment, as well as in assessing the therapeutic response of novel chemotherapeutic agents. We propose to develop a real-time tomosynthesis (TS) system to image vascular dynamics by integrating novel stationary x-ray source array technology with an existing flat-panel detector. The system will be suitable for vascular studies in modestly sized objects such as human breasts or small animals, particularly mice and rats because they are widely used for models of human diseases, including cancer. The dynamic imaging system will provide time-resolved tomographic images. After we design, fabricate, and qualify the system, we will evaluate it using phantoms to acquire real-time tomographic image data sets. These data sets will provide important information to guide the further engineering development of the stationary x-ray source technology and real-time TS system. The specific aims of this R21 proposal are to: Aim 1. Construct a real-time multi-source tomographic imaging system for vascular analysis (Year 1) Aim 2. Demonstrate stationary source operation and quantify system temporal and spatial performance using phantoms and state-of-the-art image assessment techniques. (Year 2) The stationary x-ray source proposed for demonstration in this proposal could significantly impact other areas of medical imaging technology. The potential for increased imaging speed and the implementation of novel acquisition geometries imparted by such sources could lead to the development of compact, affordable CT and digital TS systems for use in hospitals, clinics, rural areas, and laboratories, and thereby benefit both the medical care and research fields. PUBLIC HEALTH RELEVANCE: We propose to significantly improve medical imaging technology by developing an x-ray imaging system that will allow cancer researchers to take three-dimensional x-ray motion pictures. The potential for increased imaging speed, reduced system cost, and the implementation of novel acquisition geometries imparted by such a device could lead to the development of compact, affordable CT and digital tomosynthesis systems for use in hospitals, clinics, rural areas, and laboratories, and thereby benefit both the medical care and research fields.