Center for the Analysis & Management of the Multicenter AIDS Cohort Study

多中心艾滋病队列研究(MACS)，自1984年以来一直在进行的一项全面队列研究，做出了贡献 了解HIV感染的自然历史和高效抗逆转录病毒的影响 治疗(HAART)。结合遗传学、病毒学、免疫学和心理社会学的方法，利用 标本库和参与者的长期特征，扩大了对 互委会将允许在没有和存在的情况下进一步阐明艾滋病毒感染的生物学和对艾滋病毒感染的反应 并区分年龄、艾滋病毒和HAART对临床结果的影响。Mac电脑是最理想的 定位于解决这些问题，因为对6972名男性进行了长期标准化跟踪， 标本库和由生活方式相似的未感染艾滋病毒的男性组成的适当对照组 行为和人口统计数据。其他优势包括在感染前后对653名男性进行跟踪调查 已知感染日期，经验丰富的调查人员和广泛的杰出合作者网络 在艾滋病毒疾病的各个方面都有专门知识。这项申请还寻求支持将该中心扩展为 分析和管理MACS数据(CAMAC)，以提供流行病学和统计指导 Mac的研究议程。多中心协作方面，描述平衡的复杂性 在治疗的有益和不利影响之间，治疗的选择性使用和 选择适合研究问题的有效研究设计需要一个分析中心来整合 艾滋病毒科学，在流行病学、统计和数据管理方面的专业知识，为互委会成功地解决 本申请书A部分所述的科学目标。CAM ACS的具体目标是提供领导力和 质量保证体系：1)协调研究活动(包括有效的沟通、研究 方案和表格修订，定期提交与科学研究有关的统计特征 议程)；2)管理数据以便于分析(包括编辑、记录、存储和分发)；3) 在研究的设计、分析和解释方面提供统计和流行病学方面的专门知识 发展统计和流行病学方法；以及4)促进和跟踪互委会数据/样本的使用。

The Multicenter AIDS Cohort Study (MACS), a comprehensive cohort study ongoing since 1984, has contributed to the understanding of the natural history of HIV infection and the impact of highly active antiretroviral therapies (HAART). Combining genetic, virologic, immunologic and psychosocial approaches and utilizing the repository of specimens and long-term characterization of the participants, the extension of the support of the MACS will allow further elucidation of the biology of and response to HIV infection in the absence and presence of therapies, and distinguishing the effects of age, HIV and HAART on clinical outcomes. The MACS is ideally positioned to address these issues because of long-term standardized follow-up of 6,972 men, an extensive specimen repository and an appropriate control group consisting of HIV uninfected men with similar lifestyle behaviors and demographics. Additional strengths include following over 653 men before and after infection and with known dates of infection, experienced investigators and a broad network of outstanding collaborators with expertise in all aspects of HIV disease. This application further seeks support for the extension of the Center for the Analysis and Management of the MACS Data (CAMACS) to provide epidemiologic and statistical leadership to the MACS research agenda. The multicenter collaborative aspect, the complexities of characterizing the balance between beneficial and adverse effects of therapies, the selective use of treatment and the challenges inherent in choosing efficient study designs appropriate to the research questions require an analytical center to integrate HIV science with expertise in epidemiology, statistics and data management for MACS to successfully address the scientific aims as stated in Part A of this application. The specific aims of CAM ACS are to provide leadership and quality-assured systems to: 1) coordinate the research initiatives (includes effective communication, study protocol and form revision, periodic presentation of statistical characterizations pertinent to the scientific agenda); 2) manage the data to facilitate analyses (includes edit, documentation, storage, and dissemination); 3) provide statistical and epidemiological expertise in the design, analysis and interpretation of studies and to develop statistical and epidemiologic methodology; and 4) promote and track the use of MACS data/specimens.