Training Grant in Cardiac and Vascular Cell Biology

描述（由申请人提供）：该培训计划为心血管生理学和病理生理学的博士前和博士后学员提供高质量的跨学科培训经验。培训包括分子，细胞和系统生物学，重点是转化科学。我们的目标是为学员提供心脏和血管细胞生物学方面的全面，多方面的培训，并对其研究的疾病相关性给予强烈的赞赏。我们的32名教师导师来自马里兰州生物技术研究所（UMBI）的医学院（SOM），护理学院（SON）和医学生物技术中心（MBC）的13个基础和临床部门。所有的高级教师导师都是NIH资助的;我们有才华的新的初级教师，本身，密切指导提供下一波的导师培训计划该计划汇集了选定的，积极的学生和博士后研究员。培训机会广泛，包括：心血管功能的分子决定因素，心脏和血管信号通路的结构和功能研究，包括蛋白质运输。在这一更新中，人们越来越关注心血管疾病的遗传学，单个心脏和血管细胞功能的分析，以及整个组织和完整器官的生物力学特性。随着生命科学研究生课程（GPILS）下医学院（SOM）研究生课程的重组，TGE博士前申请人的质量和数量继续增加。对研究生教育的机构支持是杰出的，每年投资超过200万美元。GPILS还带头指导博士后研究员（例如职业研讨会，赠款写作研讨会）。博士前学员的课程包括8学分的核心课程，肌肉生物学，分子生物学和功能基因组学的跨学科课程。分子医学专题，一门新开设的心脏病理生理学课程，一门心血管功能实践课程。该计划提供了一个跨学科的框架，互动社区的前和博士后学员。博士后研究员参加两个心血管强化课程的学分，并与博士前学员定期会议，以介绍正在进行的工作，提供对该计划的反馈，出席并出席每周午餐时间的研究论坛，每周杂志俱乐部和年度研究务虚会。一个新的计划主任，新的指导委员会和外部咨询委员会（EAC）密切跟踪学员的进展和整个计划的成功。完成该计划的学员将准备在正常心脏和血管细胞生物学的基本问题上，在负责心脏和血管病理学的潜在机制上，以及在可能的治疗和预防上，采取一系列实验方法。

DESCRIPTION (provided by applicant): This Training Program provides a high-quality interdisciplinary training experience for pre- and postdoctoral trainees in cardiovascular physiology and pathophysiology. Training includes molecular, cell and systems biology, with an emphasis on translational science. Our goal is to provide trainees with comprehensive, multi-faceted training in cardiac and vascular cell biology, imbued with a strong appreciation of the disease relevance of their research. Our 32 faculty mentors are from 13 basic and clinical departments and divisions in the School of Medicine (SOM), School of Nursing (SON) and Medical Biotechnology Center (MBC) of the University of Maryland Biotechnology Institute (UMBI). All senior faculty mentors are NIH-funded; our talented new junior faculty, are, themselves, closely mentored provide the next wave of mentors for the Training Program The Program brings together selected, motivated students and postdoctoral fellows. Training opportunities are broad and include: molecular determinants of cardiovascular function, structure and function studies of cardiac and vascular signaling pathways, including protein trafficking. In this renewal there is increased focus, on genetics of cardiovascular diseases, analysis of the function of individual cardiac and vascular cells, as well as the biomechanical properties of whole tissues and intact organs. With reorganization of graduate studies at the School of Medicine (SOM) under the umbrella Graduate Program in Life Sciences (GPILS), quality and number of TGE predoctoral applicants continues to increase. Institutional support for graduate education is outstanding, with an annual investment over $2M. GPILS also takes the lead in mentoring postdoctoral fellows (e.g. career seminars, grant writing workshops). The coursework for pre-doctoral trainees consists of an 8 credit Core Curriculum, interdisciplinary courses in muscle biology, molecular biology and functional genomics. Topics in Molecular Medicine, a newly plaimed course on cardiac pathophysiology, and a hands on course on cardiovascular fiinction. The Program provides the framework for a cross-discipline, interactive community of pre- and postdoctoral trainees. Postdoctoral fellows take two cardiovascular intensive courses for credit and join with predoctoral trainees in regular meetings to present work-in-progress, provide feedback on the program, attend and present at weekly lunch time research forums, a weekly journal clubs and Annual Research Retreat. A new Program Director, and new Steering Committee, and an External Advisory Committee (EAC) closely track progress of the trainees and the success of the overall Program. Trainees completing this program will be prepared to bring to bear a range of experimental approaches on basic questions in normal cardiac and vascular cell biology, on the underlying mechanisms responsible for cardiac and vascular pathologies, and on their possible cure and prevention.