Studies in Children with Digestive Disorders

描述(由申请人提供)： 这份续签我的K24职业中期研究人员奖的申请是基于旧金山加州大学在儿科炎症性肠病(IBD)和儿科营养方面的研究和教学计划。加州大学旧金山分校有大量的儿科IBD患者，通过与美国其他IBD中心和加利福尼亚州的儿科IBD联盟的合作，这些患者的数量得到了扩大。正在进行的IBD调查包括利用儿科患者作为环境暴露的模型来研究IBD的病因学，与成人相比，环境暴露的影响要小得多，IBD从儿童开始的自然病史，特别是在6岁以下的儿童，开发治疗儿童IBD的新策略，以及测量这些受试者的生活质量。与儿科营养有关的项目集中在两个主题上：评估母亲营养知识和文化适应对拉美裔/西班牙裔和华裔美国儿童的影响，利用旧金山湾区的多种族人口统计数据，研究婴儿、幼儿和学龄儿童的饮食行为和肥胖的发展。营养对各种疾病状态的影响也在调查中。我们鼓励对儿科胃肠病学和营养学感兴趣的学员直接参与这些临床研究培训机会。指导计划利用这些项目来吸引年轻的研究人员参加NIH支持的儿科胃肠病和营养学研究培训计划(T32 DK 007762-28，Pi Heyman)。在我的指导下提供结构化的指导，学员可以报名参加加州大学旧金山分校临床研究硕士指导计划的课程工作，该计划为将流行病学和生物统计学方法整合到临床研究中提供了一个精心设计的环境。此外，受训者由儿科奖学金监督委员会提供指导和监督，以确保受训者获得适当水平的指导和学术进步。在我的直接监督下，鼓励和协助学员设计和实施研究项目，分析结果数据，组织口头/海报演示，并准备出版手稿。在这种丰富的环境中，学员被激励为学术生涯做准备。K24奖为我的这些教育和研究工作提供了必要的支持。

DESCRIPTION (provided by applicant): This application to renew my K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and teaching programs in pediatric inflammatory bowel disease (IBD) and pediatric nutrition at the University of California in San Francisco. Large cohorts of pediatric IBD patients are available at UCSF, augmented via collaborations with the Pediatric IBD Consortium in other IBD centers across the USA and within California. Ongoing IBD investigations include studies of the etiology of IBD utilizing the pediatric patient as a model for environmental exposures much less impacted by extraneous events compared with adults, the natural history of IBD beginning in childhood, particularly in those under six years of age, development of new strategies for treatment of pediatric IBD, and measurement of the quality of life in these subjects. Projects relating to pediatric nutrition focus on two main themes: assessing the influences of maternal nutrition knowledge and acculturation in Latino/Hispanic and Chinese-American children, taking advantage of the multi-ethnic demographics in the San Francisco Bay area to study development of eating behaviors and obesity in infants, young children and school age children. The influence of nutrition in various disease states is also under investigation. Trainees interested in pediatric gastroenterology and nutrition is encouraged to become directly involved in these clinical research training opportunities. The mentoring plan utilizes these projects to attract young investigators into the NIH-supported Research Training Program in Pediatric Gastroenterology and Nutrition (T32 DK 007762-28, PI Heyman). Structured mentoring is made available under my guidance, and trainees may enroll in coursework in the UCSF Masters in Clinical Research mentoring program that provides a well-designed environment for integration of epidemiological and biostatistical methodologies into clinical investigations. Additionally, trainees are provided with guidance and supervision by the Department of Pediatrics Scholarship Oversight Committee, which assures appropriate levels of mentoring and academic progress for the trainees. Trainees under my direct supervision are encouraged and assisted in designing and implementing research projects, analyzing resultant data, organizing oral/poster presentations, and preparing manuscripts for publication. In this enriched environment, trainees are stimulated to prepare for academic careers. The K24 award provides me with essential support for these educational and investigational efforts.