RI Network for Excellence in Biomedical and Behavioral Research

描述(由申请人提供)：该IDEA生物医学研究卓越网络(INBRE)提案的主要目的是继续加强罗德岛州生物医学和行为研究的机构能力。罗德岛大学(URI)是牵头机构，有六个伙伴机构组成了这个网络。URI的行政、生物信息学和集中设备设施中心将协调下一阶段的四个中心目标：1)继续和改进教师发展和指导；2)招聘和培训本科生和研究生研究员；3)提供对最先进设备和生物信息学资源的访问；以及4)与该州其他基础设施发展计划开发新的倡议和合作。这些目标的实现将通过网络中19名参与的教职调查人员的合作努力来实现，他们将在重点领域开展研究和教育目标 分子毒理学、细胞生物学和行为科学。新创建的教师发展计划包括以研究为基础的合作项目和以教育为基础的学生培训计划。拟议的项目将集中于各种与健康有关的问题，包括癌症、神经疾病、药物新陈代谢、传染病、组织再生和环境毒素对人类健康的影响。随着物质和人员支持的增加，生物信息学的新重点将得到加强，这将大大提高该州生物医学科学家的数据挖掘和处理能力。一项富有成效的夏季本科生研究奖学金计划将继续下去，在该计划中，学生们将获得丰富的生物医学研究方法和职业咨询方面的经验培训。一个新的协作高中外展计划计划为该地区的高中理科教师提供实践研究经验。预计在RL-INBRE计划的下一阶段实现这些和其他拟议目标将继续对罗德岛州的生物医学和行为研究和教育文化产生深远和可衡量的积极影响。 公共卫生相关性(由申请人提供)：拟议的研究将涉及广泛的人类健康问题。例如：癌症的病因和诊断研究、神经系统疾病、药物代谢和肝病、人体寄生虫病、受损组织的再生以及环境毒素对人类健康的影响。

DESCRIPTION (provided by applicant): The main purpose of this IDeA Network of Biomedical Research Excellence (INBRE) proposal is to continue to enhance institutional capacity for biomedical and behavioral research in the state of Rhode Island. The University of Rhode Island (URI) is the lead institution, with six partner institutions forming the network. The administrative, bioinformatics, and centralized equipment facility cores at URI will coordinate the four central goals of the next phase: 1) Continue and improve faculty development and mentoring; 2) Recruit and train undergraduate and graduate fellows; 3) Provide access to state-of-the-art equipment and bioinformatics resources; and 4) Develop new initiatives and collaborations with other infrastructure development programs in the state. Achievement of these goals will be accomplished by collaborative efforts of 19 participating faculty investigators in the network who will carry out research and educational objectives in the focus areas of molecular toxicology, cell biology, and behavioral science. Newly created faculty development programs include research-based collaborative projects and education-based student training initiatives. Proposed projects will focus on a variety of heath-related issues including cancer, neurological diseases, drug metabolism, infectious diseases, tissue regeneration, and the effects of environmental toxins on human health. A new emphasis in bioinformatics, strengthened by increased material and personnel support, will substantially improve the data mining and processing capabilities of biomedical scientists in the state. A productive summer undergraduate research fellowship program, in which students are given rich experiential training in biomedical research methods and career counseling, will be continued. A new collaborative highschool outreach program is planned to provide hands-on research experience for area high school science teachers. It is anticipated that meeting these and other proposed objectives in the next phase of the Rl-INBRE program will continue to have a profound and measurable positive impact on the culture for biomedical and behavioral research and education in the State of Rhode Island. PUBLIC HEALTH RELEVANCE (provided by the applicant): The proposed research will address a broad range of human health issues. Examples of these include: studies on causes and diagnosis of cancer, neurological diseases, metabolism of drugs and liver disease, parasitic human diseases, regeneration of damaged tissue, and impact of environmental toxins on human health.