A TRANSGENIC MONKEY: INHERITED NEURODEGENERATIVE DISEASES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 非人灵长类动物在人类医学研究的许多领域做出了重大贡献，因为它们是研究人类疾病的宝贵模型。最近猴子基因组信息和转基因技术的进步导致了第一个亨廷顿病转基因猴子模型的创建。转基因HD猴子出现了与人类患者相似的细胞变化和神经病理，这在啮齿动物模型中很少观察到。除了突变的亨廷顿(HTT)对猴子的神经毒性外，HD猴子还会出现类似HD患者的不自主运动和协调身体运动的困难。 我们目前有四只转基因HD猴子。一个现在是18个月，另外三个是6-8个月。在本报告所述期间，包括认知行为测试、核磁共振、代谢物和基因组图谱在内的纵向研究仍在继续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nonhuman primates have contributed significantly in many areas of human medicine research as they are invaluable models for studying human diseases. Recent advancements in monkey genomic information and transgenic technology have resulted in the creation of the first transgenic monkey model of Huntington's disease (HD). Transgenic HD monkeys develop cellular changes and neuropathologies similar to that of human patients, which are rarely observed in rodent models. Besides the neurotoxicity of mutant huntington (htt) in monkeys, HD monkeys also develop involuntary movement and difficulties in coordinating body movement similar to that of HD patients. We currently have four transgenic HD monkeys. One is now 18 months and the other three are 6-8 months. Longitudinal studies including cognitive behavioral testing, MRI, metabolite and genomic profiling continued during the reporting period.