IN VIVO SAFETY AND EFFICACY OF CAP FILM AND MICROBICIDE COMBINATIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：选择一种新的CAP阴道栓剂在恒河猴体内进行分散和全包衣研究。方法：对4只后腿抬高的动物，将阴道插管插入阴道穹隆。后端保持抬高半小时，并进行观察，以检查宫腔的分散和均匀涂层。结果/讨论：避孕套进入阴道穹隆后一小时仍未溶解。目前，我们正在研究一种新的CAP配方，它可以在合理的时间内溶解，覆盖在阴道粘膜上，并对病原性希沃克病毒具有保护作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: A new CAP vaginal pessary formulatiion was selected for dispersion and full coating study in rhesus macaques. Methods: The pessary was inserted into the vaginal vault of 4 animals with their hind legs raised. The hind end remained elevated for half hour and observations were made to examine the dispersion and even coating of the pessary. Results/Discussion: The pessary failed to dissolve even after an hour into the vaginal vault. Currently; we are working on a new formulation of CAP that can dissolve in a reasonable time, coat the vaginal mucosa and afford protection against pathogenic SHIV.