East Carolina University Bariatric Surgery Clinical Center

描述(由申请人提供)： LABS的构想是为了解决肥胖和病态肥胖患者减肥手术和新陈代谢方面的重要问题。实验室旨在探索患者特征、临床状况、血清和遗传标记、护理过程以及临床、心理社会和健康经济结果之间的关系。实验室在其前5年的主要成就是定义了探索的领域，确定了适当的指标，并招募了5105名参与者参加实验室，并在术后30天获得了99%的重要状态数据。此外，在实验2中招募了1947名参与者，收集了91%的数据，进行了6个月的随访。 实验室的扩展将建立在严谨的研究基础设施上，覆盖6个临床中心的10个临床站点，代表几个护理提供系统和患者群体。Labs招募了来自6家学术医院和4家社区医院的患者，他们正在接受33名外科医生的手术。这些网站创造了一个具有相当多样化的重要患者特征的队列。实验室包括21%的男性(范围在16%到32%之间)，9%的黑人/非裔美国人(范围在0%到24%之间)，7%的西班牙裔(范围在1%到16%之间)，10%的60岁以上的人(范围在5%到18%之间)，10%的体重指数在60公斤/平方米以上(范围在6%到27%之间)。这些特征与短期和长期结果有关，并代表了尚未得到充分表征的关键亚组，因为它们在大多数单中心队列中很少出现。重要的是，与任何单个网站相比，不同网站的多样性更有可能代表美国的减肥手术人群。

DESCRIPTION (provided by applicant): LABS was conceived to address important issues in bariatric surgery and metabolism in the obese and morbidly obese. LABS aims to explore relationships of patient characteristics, clinical conditions, serologic and genetic markers, process of care, and clinical, psychosocial and health economic outcomes. The primary achievements of LABS in its first 5 years have been to define the domains of exploration, identify appropriate metrics and enroll 5105 participants in LABS land achieve vital status data for 99% due for at 30 days post-surgery. In addition, 1947 participants in LABS 2 have been recruited with data collected for 91% for 6 months follow-up. An extension of LABS would build on the rigorous research infrastructure across 10 clinical sites at the 6 clinical centers representing several care delivery systems and patient populations. LABS enrolls patients from 6 academic and 4 community hospitals undergoing operations by 33 surgeons. These sites have created a cohort with considerable diversity of important patient characteristics. LABS includes 21% males (range across sites 16% to 32%), 9% Black/African-Americans (range 0% to 24%), 7% Hispanics (range 1% to 16%), 10% age 60+ years (range 5%-18%), and 10% BMI 60+ kg/m2 (range 6% to 27%). These features have been linked to short and long-term outcomes and represent critical subgroups that have not been adequately characterized because they appear infrequently in most single-center cohorts. Importantly, the diversity across sites is more likely to represent the bariatric surgery population in the U.S. than would be possible from any individual site.