University of Utah Biomedical Research Core Center (P30) in Metabolism and CVD

描述（由申请人提供）：糖尿病和肥胖是心血管疾病的主要危险因素，其发病率在美国以惊人的速度增加。迫切需要提高我们对导致这些疾病及其并发症的基本机制的认识。犹他州大学的代谢兴趣小组（Metabolism Interest Group，简称EMT）是一个跨学科小组，由17个实验室组成，重点研究燃料和金属代谢的改变如何导致慢性代谢紊乱，如糖尿病及其心血管并发症。自2002年以来，该小组的调查记录非常出色，在这一领域发表了200多份经同行审查的原创出版物。该研究的一个主要目标是确定线粒体功能障碍导致糖尿病、肥胖及其心血管并发症的新机制。我们已经建立了核心活动，如线粒体表型核心设施，心血管表型核心设施，整个动物代谢表型核心设施和代谢组学核心设施。内分泌代谢和糖尿病的部门是代谢兴趣小组的一个组成部分，并积极招募初级教师，其研究活动和兴趣将与代谢兴趣小组的广泛目标相一致。具体而言，候选人将带来线粒体生物能量学分析领域的额外专业知识，因为它们涉及心血管风险因素的调节，如肥胖和血脂异常以及肥胖相关的心功能障碍。有从内科和生物化学系招聘在这方面的初级教师强有力的机构支持。目前已有办公室和研究室可供这些新聘人员使用。该应用程序将针对国家心肺和血液研究所，其目标与代谢兴趣小组的目标最为一致。 糖尿病和肥胖症的患病率正在以惊人的速度增加，并且是心血管疾病的主要危险因素。目前迫切需要对这些疾病中CVD的发病机制和治疗进行调查，并且最有可能在跨学科研究小组中取得进展，例如犹他州医学院的代谢兴趣小组。

DESCRIPTION (provided by applicant): Diabetes and obesity are major risk factors for cardiovascular disease, whose incidence is increasing in the United States at an alarming rate. There is an urgent need to increase our understanding of fundamental mechanisms that lead to these disorders and their complications. The Metabolism Interest Group (MIG) at the University of Utah is an interdisciplinary group comprising 17 laboratories with a focus on studying how altered fuel and metal metabolism leads to chronic metabolic disorders such as diabetes and its cardiovascular complications. The investigative record of this group is outstanding with over 200 original peer reviewed publications in this area since 2002. A major goal of the MIG is to identify novel mechanisms by which mitochondrial dysfunction contributes to diabetes, obesity and their cardiovascular complications. We have established core activities such as a mitochondrial phenotyping core facility, a cardiovascular phenotyping core facility a whole animal metabolic phenotyping core facility and a metabolomics core facility. The Division of Endocrinology Metabolism and Diabetes is an integral member of the Metabolism Interest Group and is actively recruiting junior faculty whose research activity and interests will be consonant with the broad goals of the Metabolism Interest Group. Specifically, candidates will bring additional expertise in the area of mitochondrial bioenergetics analyses as they relate to the regulation of cardiovascular risk factors such as obesity and dyslipidemia and obesity-associated cardiac dysfunction. There is strong institutional support from the Department of Internal Medicine and Biochemistry for recruiting junior faculty in this area. Office and research space to accommodate these recruits is currently available. The application will be targeted to the National Heart Lung and Blood Institute, whose goals most closely align with those of the Metabolism Interest Group. The prevalence of diabetes and obesity are increasing at an alarming rate, and are major risk factors for cardiovascular disease. There is a pressing need for investigation into the pathogenesis and treatment of CVD in these disorders, and progress is most likely to be made in interdisciplinary research groups such as the Metabolism Interest Group of the University of Utah School of Medicine.