Biomedical Research Core Center (P30) on Fetal Programming

描述（由申请人提供）：这是NIH P30生物医学研究核心中心申请（RFA-OD-09-005）关于胎儿程序设计在肥胖诱导的心血管疾病发展中的应用。该请求用于支持在营养科学研究生中心（GCNS）任命的一名新调查员的薪金和启动费用，该中心是医学院的一个多学科研究和研究生项目。通过饮食控制作为促进成年后代肥胖和心血管疾病的机制的胎儿规划研究领域将补充和扩展NIH资助的肥胖和心血管疾病生物医学研究卓越中心（COBRE）。专门的研究核心，广泛的大学核心设施，以及建立的指导机制，以促进独立研究项目的发展，在研究领域内实现R01竞争力。新招募的教员将在GCNS高度协作的环境中被分配专门的研究空间，并提供常用设备和专门的核心，用于分析测量、组织病理学、血压的无线电遥测测量和小鼠全身代谢。目标研究领域补充和扩展了目前专注于确定成人饮食引起的肥胖与心血管疾病发展相关机制的研究。在这个姐妹P30中心，新招募的教员将研究通过孕期饮食控制的胎儿计划对成年后代肥胖和心血管疾病发展的影响。鉴于肥胖在美国越来越普遍，确定母亲肥胖通过西方饮食对后代疾病发展的影响是很重要的。此外，这些姊妹中心通过对比肥胖在成人发病的肥胖引起的心血管疾病发展过程中的影响，跨越了当前研究的广度。我们将利用我们在指导方面的现有优势和我们在确定的研究领域内的重点研究核心，以确保新的研究人员开发对NIH HLBI任务具有临床意义的独立研究项目。

DESCRIPTION (provided by applicant): This is a NIH P30 Biomedical Research Core Center Application (RFA-OD-09-005) on Fetal Programming in the Development of Obesity-induced Cardiovascular Diseases. The request is for support of salary and start-up costs for recruit of one new investigator for appointment within the Graduate Center for Nutritional Sciences (GCNS), a multidisciplinary research and graduate program within the College of Medicine. The research area of fetal programming through dietary manipulation as a mechanism promoting obesity and cardiovascular disease in adult offspring will complement and extend an NIH funded Center of Biomedical Research Excellence (COBRE) on obesity and cardiovascular diseases. Specialized research cores, extensive University Core Facilities, and established mentoring mechanisms are in place to promote development of an independent research program towards R01 competitiveness within the research area. The new faculty recruit will be assigned dedicated research space within the highly collaborative environment of the GCNS, with availability to common use equipment and specialized cores for analytical measurements, tissue pathology, radiotelemetry measurement of blood pressure, and whole body metabolism in mice. The targeted research area complements and extends studies currently focused on identification of mechanisms linking diet-induced obesity in adults in the development of cardiovascular disease. In this sister P30 Center, new faculty recruits will examine effects of fetal programming through dietary manipulation during pregnancy on the development of obesity and cardiovascular diseases in adult offspring. Given the increasing prevalence of obesity in the US, it is important to identify the impact of maternal obesity, through consumption of a western diet, on disease development in offspring. Moreover, these sister Centers span the breadth of current research by contrasting effects of obesity during development from adult onset obesity-induced cardiovascular disease. We will use our existing strengths in mentoring and our focused research cores within the defined area of study to assure that new investigators develop independent research programs of clinical significance to the missions of NIH HLBI.