The Role of Viruses in Human Cancer

描述(由申请人提供)：我们建议招聘一位杰出的初级科学家作为终身教授，以增强和加强我们在肿瘤病毒学方面的核心中心。到目前为止，特定的人类肿瘤病毒与至少15%-20%的人类癌症有因果关系，并被广泛怀疑与更多的癌症有关。我们已经确定了三个关键项目需要的研究领域：病毒免疫学(包括先天免疫和疫苗开发)、病毒复制和致癌的系统生物学分析，以及抗病毒治疗。这笔赠款的批准将在威斯康星大学麦迪逊分校的两个世界著名的研究中心--分子病毒学研究所(IMV)和麦卡德尔癌症研究实验室(McArdle)--之间建立一个新的联合职位，麦卡德尔实验室将提供正式的终身教职之家，而分子病毒学研究所将提供实验室/办公室空间以及额外的物理和行政资源。招聘工作将在做出积极的资助决定后立即开始，并将遵循我们传统的、严格的遴选程序，多年来已被证明在确定和招聘优秀年轻教师方面取得了成功。作为这笔赠款的一个关键目标，我们还将根据NIH的目标，将招聘重点放在初级女性和/或少数族裔教职员工上。与IMV/McArdle的其他教员一样，新聘用的人员将整合到这两个研究中心提供的病毒学核心的工作人员中。此外，这位新员工将成为全校研究生项目、保罗·P·卡伯恩综合癌症中心(UWCCC)和威斯康星州传染病中心的成员。按照我们一贯的政策，所有新招聘的教员都会得到广泛的个人指导，并通过一个由5名高度参与的资深教员组成的实践指导委员会进行协调。我们的年轻教员在最初的2-3年里受到高度保护，不会受到广泛的教学和行政或委员会服务承诺的影响，以便他们有时间专注于新的独立职位，并建立他们对受人尊敬的、富有成效的世界级项目的研究。有多种机制用于评估该计划对我们进行多学科研究的能力的影响。

DESCRIPTION (provided by applicant): We propose to recruit an outstanding junior scientist as a tenure track assistant professor to augment and strengthen our core center In tumor virology. To date, specific human tumor viruses have been causally associated with at least 15-20% of all human cancers and are widely suspected to contribute to additional cancers. We have identified three research areas as critical program needs: viral immunology (including Innate immunity and vaccine development), systems biology analysis of viral replication and oncogenesis, and antiviral therapeutics. Approval of this grant would trigger the creation of a new joint position between two world-renowned research centers at the University of Wisconsin-Madison, the Institute for Molecular Virology (IMV) and the McArdle Laboratory for Cancer Research (McArdle), with McArdle providing the official tenure home and IMV providing laboratory/office space and additional physical and administrative resources. Recruitment efforts would begin immediately after a positive funding decision and would follow our traditional, rigorous selection processes that have proven successful over many years in identifying and recruiting outstanding young faculty. As a key objective of this grant, we also would focus the recruitment on a junior woman and/or minority faculty member, consistent with the NIH goals. As with other IMV/McArdle faculty, the new hire would be integrated within the staff of the virology core provided by these two research centers. In addition, the new hire would become a member of campus-wide graduate programs, the Paul P. Carbone Comprehensive Cancer Center (UWCCC) and the Wisconsin Center for Infectious Disease. As has always been our policy all new faculty hires are provided extensive personal mentoring that is coordinated through a hands-on mentoring committee of 5 highly-involved senior faculty. Our young faculty are highly protected in their first 2-3 years from extensive teaching and administrative or committee service commitments to allow them time to focus on their new independent positions, and to establish their research into respected, productive world-class programs. Multiple mechanisms are in place for evaluating the impact of this program on our capability to conduct multidisciplinary research.