Molecular and Cellular Mechanisms underlying function and dysfunction of Neural C

描述(由申请人提供)：该申请的目标是招募新的研究人员的跨学科计划，其重点是在健康和疾病的神经回路的结构和功能。神经回路与行为计划(PNCB)将：1)深入探索神经回路的生物学及其产生的行为；2)采用高度跨学科的方法解决该领域最重要的问题。PNCB建立在加州大学圣地亚哥分校以及索尔克研究所、斯克里普斯研究所和伯纳姆研究所拥有120多名成员的极其丰富的神经科学社区的基础上。PNCB是医学院通过神经科学系和生物科学部通过神经生物学部门最近联合创建的。该部门的主席(Anirvan Ghosh)和部门主席(William Mobley)已将精力和资源投入到他们认为是神经科学最重要的下一步--“破译正常大脑和受神经疾病影响的大脑中的神经回路的结构和功能”。PNCB的现有成员是罗伯特·马利诺、杰弗里·艾萨克森和马西莫·斯坎齐亚尼。所有员工都住在CMG大楼内；新员工也将驻扎在那里，以加强职业发展的方方面面。其中一名新兵将开发和使用新的光遗传工具来实现成像功能。另一项研究将检查包括疾病模型在内的小鼠模型的电路功能。因此，他们将为加州大学圣地亚哥分校带来新的技术和概念，同时从一个有教养的神经科学界中受益匪浅。PNCB还将包括大约20名来自更大社区的额外成员，他们的工作是在从基因到更高级别行为的神经回路中进行分析。通过在PNCB成员与加州大学圣迭戈分校的临床医生和科学家(如化学、药物化学、物理学和心理学)之间建立密切联系，这一新项目无疑将培养对神经回路生物学的许多新见解。事实上，我们希望我们的新兵和他们的同事将改变我们对神经回路的组织和功能的理解。 与公共健康相关：所有的大脑功能都是通过激活特定的神经回路来实现的。相反，所有的大脑功能障碍都是由于特定回路的中断。因为我们对神经回路的结构和功能知之甚少，所以我们不知道回路在大脑紊乱中是如何失效的。在此，我们建议招募一个多学科团队的关键成员，以探索回路在健康和疾病中的功能。

DESCRIPTION (provided by applicant): This application targets the recruitment of new investigators o an interdisciplinary program whose focus is the structure and function of neural circuits in health and disease. The Program in Neural Circuits and Behavior (PNCB) will: 1) explore intensively on the biology of neural circuits and the behaviors they produce; and 2) tackle the most important questions in this field using a highly interdisciplinary approach. The PNCB builds on an extraordinarily rich neurosciences community of more than 120 members located at UCSD as well as at the Salk Institute, Scripps Research Institute, and the Burnham Institute. The PNCB is a recent joint creation of the School of Medicine, through the Department of Neurosciences, and the Division of Biological Sciences, through the Section on Neurobiology. The Chairs of the Section (Anirvan Ghosh) and the Department (William Mobley) have committed energy and resources to what they view as the most important next step for the neurosciences -" to decipher the structure and function neural circuits in the normal brain and in brains affected by neurological disorders". PNCB existing members are Robert Malinow, Jeffrey Isaacson and Massimo Scanziani. All occupy space in the CMG building; the new recruits would also be located there to enhance all aspects of career development. One of the new recruits would develop and use new optogenetic tools for imaging function. The other would examine circuit function in mouse models, including models of disease. Thus, they would bring new technologies and concepts to UCSD while benefitting immensely from a nurturing neuroscience community. The PNCB will also include about 20 additional members of the greater community whose work is in neural circuits at levels of analysis ranging from genes to higher order behaviors. By establishing close links between PNCB members and clinicians and scientists in the greater UCSD campus (e.g. Chemistry, Pharmaceutical Chemistry, Physics, and Psychology), this new program will undoubtedly foster many new insights into the biology of neural circuits. Indeed, it is our expectation that our recruits and their colleagues will transform our understanding of the organization and function of neural circuits. PUBLIC HEALTH RELEVANCE: All brain functions are carried out through the activation of specific neural circuits. Conversely, all disorders of brain function are due to disruption of specific circuits. Because we know little about the structure and function of neural circuits, we do not understand how circuits fail in brain disorders. Herein we propose to recruit key members of a multidisciplinary team to explore the function of circuits in health and disease.