NEUROCOGNITIVE OUTCOMES OF INFANTS OF DIABETIC MOTHERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前这项建议的目标是继续研究我们的儿童群体，因为他们进入小学。我们的努力具体集中在三个领域。 首先，我们打算更具体地记录到目前为止观察到的功能和结构缺陷的性质：因此，什么类型的记忆受损，以及海马体的损伤程度如何？ 第二，我们试图确定是否出现其他认知功能的赤字，因为我们的研究人群过渡到学龄;具体来说，我们观察到纹状体或前额叶功能的赤字？ 那么，这些缺陷与学校表现之间是否存在关联？ 最后，我们希望进一步表征IDM中常见的不良胎儿环境损害了哪些神经回路;具体而言，确认我们对海马损伤的预测（从海马体积和/或代谢减少推断）和/或我们是否观察到纹状体损伤，和/或我们是否观察到由于产前缺铁导致的白色物质减少。 我们将通过对我们目前的IDM和对照儿童样本进行详细的电生理（ERPs）、代谢（fMRI）、解剖（MRI）和行为（神经心理学）研究来解决这些问题。 鉴于约10%的妊娠合并产妇糖尿病，目前的项目对公共卫生具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this current proposal is to continue to study our cohort of children as they enter the elementary school years. We are focusing our efforts specifically on three areas. First, we intend to document more specifically the nature of the functional and structural deficits observed to date: thus, what types of memory are impaired, and how extensive is the damage to the hippocampus? Second, we seek to determine whether deficits in other cognitive functions emerge as our study populations makes the transition to school age; specifically, do we observe deficits in striatal or prefrontal functions? And, is there an association between such deficits and school performance? Finally, we wish to characterize further what neural circuits have been compromised by the adverse fetal environment that is common among IDMs; specifically, confirm our prediction of hippocampal damage (as inferred from reduced hippocampal volume and/or metabolism) and/or whether we observe damage to striatum, and/or whether we observe reductions in white matter due to prenatal iron deficiency. We will address these questions by conducting detailed electrophysiological (ERPs), metabolic (fMRI), anatomic (MRI), and behavioral (neuropsychologic) studies on our current samples of IDMs and comparison children. Given that approximately 10% of all pregnancies are complicated by maternal diabetes, the current project has important implications for public health.