ARGININE TREATMENT FOR ALCOHOLIC HEPATITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是通过血液测试来测试饮食精氨酸对减轻肝脏损伤的有效性。将有两个小组。第一组将把精氨酸以混合到冰淇淋或果冻中的粉末的形式添加到他们的饮食中，剂量是正常饮食中的4倍。由于饮食中正常的精氨酸量大约是能量摄入量的1%，你将获得饮食中4%的能量作为精氨酸。第二组将接受安慰剂治疗，包括在饮食中的冰淇淋或果冻中加入葡萄糖粉。如果患者患有轻度和中度酒精性肝炎，则进入研究。这是由df分数&lt；33决定的。DF评分是肝损伤的标准标记物。 患者将在综合临床研究中心(GCRC)花费28-30天来测量饮食中额外精氨酸的影响。在建立了临床稳定性后，研究患者将进行几次测试，并将测量他们的肝脏使用非放射性亮氨酸输注产生多少白蛋白。此外，白蛋白损失将使用白蛋白的放射性同位素进行两次测量。如果患者有腹水(腹水)，他们将不会进行这项测试。将鼓励患者饮食中80%或更多的食物。如果他们不能摄入至少80%的饮食，他们将被要求提前离开研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test the effectiveness of dietary arginine to reduce liver injury as measured by blood tests. There will be two groups. The first group will have dietary arginine added to their diet in the form of powder mixed into ice cream or sherbet at 4 times the normal amount in the diet. Since the normal amount of arginine in the diet is approximately 1% of the energy intake, you will receive 4% of the energy in the diet as arginine. The second group will receive the placebo treatment consisting of glucose powder added into the ice cream or sherbet in the diet. Patients are entered into the study if they have mild and moderate alcoholic hepatitis. This is determined by having a DF score <33. The DF score is a standard marker of liver injury. Patients will spend 28-30 days in the General Clinical Research Center (GCRC) to measure the effects of additional arginine in the diet. After clinical stability is established, study patients will have several tests and and will also have measurement of how much albumin their liver makes using non-radioactive infusion of leucine. In addition, albumin loss will be measured twice by using a radioisotope of albumin. They will not have this test if the patient has ascites (fluid in the abdomen). Patients will be encouraged to eat 80% or more of their diet. If they are not able to ingest at least 80% of their diet, they will asked to leave the study early.